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dc.contributorColtell Simón, Oscar
dc.contributor.authorMedina Remón, A.
dc.contributor.authorTresserra-Rimbau, Anna
dc.contributor.authorPons, A.
dc.contributor.authorTur, Josep
dc.contributor.authorMartorell, M.
dc.contributor.authorRos, E.
dc.contributor.authorBuil-Cosiales, Pilar
dc.contributor.authorSacanella, E.
dc.contributor.authorCovas Planells, María Isabel
dc.contributor.authorCorella, Dolores
dc.contributor.authorSalas-Salvadó, Jordi
dc.contributor.authorGómez Gracia, Enrique
dc.contributor.authorRuiz-Gutiérrez, Valentina
dc.contributor.authorOrtega-Calvo, Manuel
dc.contributor.authorGarcía Valdueza, M.
dc.contributor.authorArós, Fernando
dc.contributor.authorSaez, G.T.
dc.contributor.authorSerra-Majem, Lluis
dc.contributor.authorPintó, Xavier
dc.contributor.authorVinyoles, E.
dc.contributor.authorEstruch, Ramon
dc.contributor.authorLamuela Raventós, Rosa María
dc.date.accessioned2016-11-15T13:22:45Z
dc.date.available2016-11-15T13:22:45Z
dc.date.issued2015
dc.identifier.citationMEDINA-REMÓN, A., et al. Effects of total dietary polyphenols on plasma nitric oxide and blood pressure in a high cardiovascular risk cohort. The PREDIMED randomized trial. Nutrition, Metabolism and Cardiovascular Diseases, 2015, vol. 25, no 1, p. 60-67.ca_CA
dc.identifier.urihttp://hdl.handle.net/10234/164440
dc.description.abstractBackground and aim: Hypertension is one of the main cardiovascular risk factors in the elderly. The aims of this work were to evaluate if a one-year intervention with two Mediterranean diets (Med-diet) could decrease blood pressure (BP) due to a high polyphenol consumption, and if the decrease in BP was mediated by plasma nitric oxide (NO) production. Methods and results: An intervention substudy of 200 participants at high cardiovascular risk was carried out within the PREDIMED trial. They were randomly assigned to a low-fat control diet or to two Med-diets, one supplemented with extra virgin olive oil (Med-EVOO) and the other with nuts (Med-nuts). Anthropometrics and clinical parameters were measured at baseline and after one year of intervention, as well as BP, plasma NO and total polyphenol excretion (TPE) in urine samples. Systolic and diastolic BP decreased significantly after a one-year dietary intervention with Med-EVOO and Med-nuts. These changes were associated with a significant increase in TPE and plasma NO. Additionally, a significant positive correlation was observed between changes in urinary TPE, a biomarker of TP intake, and in plasma NO (Beta = 4.84; 95% CI: 0.57–9.10). Conclusions: TPE in spot urine sample was positively correlated with plasma NO in Med-diets supplemented with either EVOO or nuts. The statistically significant increases in plasma NO were associated with a reduction in systolic and diastolic BP levels, adding to the growing evidence that polyphenols might protect the cardiovascular system by improving the endothelial function and enhancing endothelial synthesis of NO.ca_CA
dc.description.sponsorShipWe would like to thank all the volunteers involved in the PREDIMED study for their valuable cooperation. This study was supported in part by CICYT (AGL2010-22319-C03 and AGL2013-49083-C3-1-R), RD06/0045 and CIBEROBN from the ISCIII (Spanish Ministry of Science and Innovation, MICINN), Quality Group from Generalitat de Catalunya 2009-SGR-724 and 2014-SGR-773, and Grant of support to research groups no.35/2011 (Balearic Islands Gov. and EU FEDER funds). A.M.-R. thanks the “Juan de la Cierva” postdoctoral program (JCI-2012-13463) from MEC. A.T.-R. would like to thank the ISCIII for granting her a predoctoral fellowship (FI10/00265).ca_CA
dc.format.mimetypeapplication/pdfca_CA
dc.language.isoengca_CA
dc.publisherElsevierca_CA
dc.relation.isPartOfNutrition, Metabolism and Cardiovascular Diseases, 2015, vol. 25, no 1ca_CA
dc.rights.urihttp://rightsstatements.org/vocab/CNE/1.0/*
dc.subjectBlood pressureca_CA
dc.subjectNitric oxideca_CA
dc.subjectPREDIMED studyca_CA
dc.subjectPolyphenolsca_CA
dc.subjectUrinary polyphenolca_CA
dc.titleEffects of total dietary polyphenols on plasma nitric oxide and blood pressure in a high cardiovascular risk cohort. The PREDIMED randomized trialca_CA
dc.typeinfo:eu-repo/semantics/articleca_CA
dc.identifier.doihttp://dx.doi.org/10.1016/j.numecd.2014.09.001
dc.rights.accessRightsinfo:eu-repo/semantics/restrictedAccessca_CA
dc.relation.publisherVersionhttp://www.sciencedirect.com/science/article/pii/S0939475314002877ca_CA
dc.type.versioninfo:eu-repo/semantics/publishedVersion


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