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dc.contributor.authorFalomir Ventura, Eva
dc.contributor.authorLucas, Ricardo
dc.contributor.authorPeñalver, Pablo
dc.contributor.authorMartí Centelles, Rosa
dc.contributor.authorDupont, Alexia
dc.contributor.authorZafra Gómez, Alberto
dc.contributor.authorCarda Usó, Miguel
dc.contributor.authorMorales, Juan C.
dc.date.accessioned2016-09-19T09:12:28Z
dc.date.available2016-09-19T09:12:28Z
dc.date.issued2016-06
dc.identifier.citationFALOMIR, Eva, et al. Cytotoxic, antiangiogenic and antitelomerase activity of glucosyl‐and acyl‐resveratrol prodrugs and resveratrol sulfate metabolites. ChemBioChem, Volume 17, Issue 14, 2016.ca_CA
dc.identifier.urihttp://hdl.handle.net/10234/162655
dc.description.abstractResveratrol (RES) is a natural polyphenol with relevant and varied biological activity. However, its low bioavailability and rapid metabolism to its glucuronate and sulfate conjugates has opened a debate on the mechanisms underlying its bioactivity. RES prodrugs are being developed to overcome these problems. We have synthesized a series of RES prodrugs and RES sulfate metabolites (RES-S) and evaluated their biological activities. RES glucosylated prodrugs (RES-Glc) were more cytotoxic in HT-29 and MCF-7 cells than RES itself whereas RES-S showed similar or higher cytotoxicity than RES. VEGF production was decreased by RES-Glc, and RES-disulfate (RES-diS) diminished it even more than RES. Finally, RES-Glc and RES-diS inhibited hTERT gene expression to a higher extent than RES. In conclusion, resveratrol prodrugs are promising candidates as anticancer drugs. In addition, RES-S showed distinct biological activity, thus indicating they are not simply RES reservoirs.ca_CA
dc.description.sponsorShipFinancial support has been granted by the Spanish Government (Ministerio de Economía y Competitividad, projects CTQ2011-27560 and CTQ2012-35360), by the Consellería d’Empresa, Universitat i Ciencia de la Generalitat Valenciana (projects PROMETEO/2013/027) and by the Universitat Jaume I (project PI-1B-2011-37).ca_CA
dc.format.extent5 p.ca_CA
dc.format.mimetypeapplication/pdfca_CA
dc.language.isoengca_CA
dc.relation.isPartOfChemBioChem, Volume 17, Issue 14, July 2016.ca_CA
dc.rightsCopyright © 1999-2016 John Wiley & Sons, Inc. All Rights Reservedca_CA
dc.subjectresveratrolca_CA
dc.subjectpolyphenolca_CA
dc.subjectprodrugca_CA
dc.subjectmetaboliteca_CA
dc.subjectsulfateca_CA
dc.subjectcytotoxicityca_CA
dc.subjectantiproliferationca_CA
dc.subjectangiogenesisca_CA
dc.titleCytotoxic, antiangiogenic and antitelomerase activity of glucosyl- and acyl- resveratrol prodrugs and resveratrol sulfate metabolitesca_CA
dc.typeinfo:eu-repo/semantics/articleca_CA
dc.identifier.doihttp://dx.doi.org/10.1002/cbic.201600084
dc.rights.accessRightsinfo:eu-repo/semantics/openAccessca_CA
dc.relation.publisherVersionhttp://onlinelibrary.wiley.com/wol1/doi/10.1002/cbic.201600084/abstractca_CA


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