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dc.contributor.authorSalamone, John D.
dc.contributor.authorCorrea Sanz, Mercè
dc.contributor.authorYohn, Samantha E.
dc.contributor.authorLópez Cruz, Laura
dc.contributor.authorSan Miguel Segura, Noemí
dc.contributor.authorAlatorre, Luisa
dc.date.accessioned2016-09-13T14:45:42Z
dc.date.available2016-09-13T14:45:42Z
dc.date.issued2016
dc.identifier.issn0376-6357
dc.identifier.issn1872-8308
dc.identifier.urihttp://hdl.handle.net/10234/162474
dc.description.abstractThis review paper is focused upon the involvement of mesolimbic dopamine (DA) and related brain systems in effort-based processes. Interference with DA transmission affects instrumental behavior in a manner that interacts with the response requirements of the task, such that rats with impaired DA transmission show a heightened sensitivity to ratio requirements. Impaired DA transmission also affects effort-related choice behavior, which is assessed by tasks that offer a choice between a preferred reinforcer that has a high work requirement vs. less preferred reinforcer that can be obtained with minimal effort. Rats and mice with impaired DA transmission reallocate instrumental behavior away from food-reinforced tasks with high response costs, and show increased selection of low reinforcement/low cost options. Tests of effort-related choice have been developed into models of pathological symptoms of motivation that are seen in disorders such as depression and schizophrenia. These models are being employed to explore the effects of conditions associated with various psychopathologies, and to assess drugs for their potential utility as treatments for effort-related symptoms. Studies of the pharmacology of effort-based choice may contribute to the development of treatments for symptoms such as psychomotor slowing, fatigue or anergia, which are seen in depression and other disorders.ca_CA
dc.description.sponsorShipUS NIH/NIMH MH078023 Shire Fundacio UJI/Bancaixa P1.1B2010-43ca_CA
dc.format.extent15 p.ca_CA
dc.language.isoengca_CA
dc.publisherElsevierca_CA
dc.relation.isPartOfBehavioural Processes 127 (2016) 3–17ca_CA
dc.rights© 2016 Elsevier B.V. All rights reserved.ca_CA
dc.subjectDopamineca_CA
dc.subjectAdenosineca_CA
dc.subjectEffortca_CA
dc.subjectWorkca_CA
dc.subjectReinforcementca_CA
dc.subjectBehavioral economicsca_CA
dc.subjectDepressionca_CA
dc.titleThe pharmacology of effort-related choice behavior: Dopamine, depression, and individual differencesca_CA
dc.typeinfo:eu-repo/semantics/articleca_CA
dc.identifier.doihttp://dx.doi.org/10.1016/j.beproc.2016.02.008
dc.rights.accessRightsinfo:eu-repo/semantics/restrictedAccessca_CA
dc.relation.publisherVersionhttp://www.sciencedirect.com/science/article/pii/S0376635716300298ca_CA


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