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dc.contributor.authorMartí-Centelles, Rosa
dc.contributor.authorFalomir, Eva
dc.contributor.authorCarda, Miguel
dc.contributor.authorNieto, Carla I.
dc.contributor.authorCornago, M. Pilar
dc.contributor.authorClaramunt, Rosa M.
dc.date.accessioned2016-07-14T07:58:28Z
dc.date.available2016-07-14T07:58:28Z
dc.date.issued2016-07
dc.identifier.citationMARTÍ‐CENTELLES, Rosa, et al. Effects of Curcuminoid Pyrazoles on Cancer Cells and on the Expression of Telomerase Related Genes. Archiv der Pharmazie, Volume 349, Issue 7, July 2016, pages 532–538.ca_CA
dc.identifier.urihttp://hdl.handle.net/10234/161696
dc.description.abstractA group of 13 curcuminoid pyrazoles was investigated for their cytotoxicity on three tumoral cell lines (HT-29, MCF-7, and HeLa) and one non-tumoral human cell line (HEK-293). The values obtained were compared with those of curcumin. A subset of selected derivatives was also studied for their ability to downregulate expression of the hTERT and c-Myc genes, which are both involved in telomerase activity.ca_CA
dc.description.sponsorShipWe are grateful to Professor José Elguero, from the Real Academia de Ciencias Exactas Físicas y Naturales of Spain, for his advice during the development of this work. This work was supported by Ministerio de Economía y Competitividad of Spain (CTQ2014-56833-P) and by the Consellería d'Empresa, Universitat i Ciència de la Generalitat Valenciana (ACOMP09/113) and by University Jaume I (PI-1B2015-75). R.M.-C. thanks the University Jaume I for a predoctoral fellowship. We thank Rafael Pulido for providing HT-29 cells.ca_CA
dc.format.extent6 p.ca_CA
dc.format.mimetypeapplication/pdfca_CA
dc.language.isoengca_CA
dc.publisherWileyca_CA
dc.relation.isPartOfArchiv der Pharmazie Volume 349, Issue 7, July 2016ca_CA
dc.rights© 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheimca_CA
dc.rights.urihttp://rightsstatements.org/vocab/InC/1.0/*
dc.subjectCytotoxicityca_CA
dc.subjectCurcuminoid pyrazolesca_CA
dc.subjectGene downregulationca_CA
dc.subjectTelomeraseca_CA
dc.titleEffects of Curcuminoid Pyrazoles on Cancer Cells and on the Expression of Telomerase Related Genesca_CA
dc.typeinfo:eu-repo/semantics/articleca_CA
dc.identifier.doihttp://dx.doi.org/10.1002/ardp.201600067
dc.rights.accessRightsinfo:eu-repo/semantics/restrictedAccessca_CA
dc.relation.publisherVersionhttp://onlinelibrary.wiley.com/doi/10.1002/ardp.201600067/fullca_CA


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