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Effects of Curcuminoid Pyrazoles on Cancer Cells and on the Expression of Telomerase Related Genes
dc.contributor.author | Martí-Centelles, Rosa | |
dc.contributor.author | Falomir, Eva | |
dc.contributor.author | Carda, Miguel | |
dc.contributor.author | Nieto, Carla I. | |
dc.contributor.author | Cornago, M. Pilar | |
dc.contributor.author | Claramunt, Rosa M. | |
dc.date.accessioned | 2016-07-14T07:58:28Z | |
dc.date.available | 2016-07-14T07:58:28Z | |
dc.date.issued | 2016-07 | |
dc.identifier.citation | MARTÍ‐CENTELLES, Rosa, et al. Effects of Curcuminoid Pyrazoles on Cancer Cells and on the Expression of Telomerase Related Genes. Archiv der Pharmazie, Volume 349, Issue 7, July 2016, pages 532–538. | ca_CA |
dc.identifier.uri | http://hdl.handle.net/10234/161696 | |
dc.description.abstract | A group of 13 curcuminoid pyrazoles was investigated for their cytotoxicity on three tumoral cell lines (HT-29, MCF-7, and HeLa) and one non-tumoral human cell line (HEK-293). The values obtained were compared with those of curcumin. A subset of selected derivatives was also studied for their ability to downregulate expression of the hTERT and c-Myc genes, which are both involved in telomerase activity. | ca_CA |
dc.description.sponsorShip | We are grateful to Professor José Elguero, from the Real Academia de Ciencias Exactas Físicas y Naturales of Spain, for his advice during the development of this work. This work was supported by Ministerio de Economía y Competitividad of Spain (CTQ2014-56833-P) and by the Consellería d'Empresa, Universitat i Ciència de la Generalitat Valenciana (ACOMP09/113) and by University Jaume I (PI-1B2015-75). R.M.-C. thanks the University Jaume I for a predoctoral fellowship. We thank Rafael Pulido for providing HT-29 cells. | ca_CA |
dc.format.extent | 6 p. | ca_CA |
dc.format.mimetype | application/pdf | ca_CA |
dc.language.iso | eng | ca_CA |
dc.publisher | Wiley | ca_CA |
dc.relation.isPartOf | Archiv der Pharmazie Volume 349, Issue 7, July 2016 | ca_CA |
dc.rights | © 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim | ca_CA |
dc.rights.uri | http://rightsstatements.org/vocab/InC/1.0/ | * |
dc.subject | Cytotoxicity | ca_CA |
dc.subject | Curcuminoid pyrazoles | ca_CA |
dc.subject | Gene downregulation | ca_CA |
dc.subject | Telomerase | ca_CA |
dc.title | Effects of Curcuminoid Pyrazoles on Cancer Cells and on the Expression of Telomerase Related Genes | ca_CA |
dc.type | info:eu-repo/semantics/article | ca_CA |
dc.identifier.doi | http://dx.doi.org/10.1002/ardp.201600067 | |
dc.rights.accessRights | info:eu-repo/semantics/restrictedAccess | ca_CA |
dc.relation.publisherVersion | http://onlinelibrary.wiley.com/doi/10.1002/ardp.201600067/full | ca_CA |
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