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dc.contributor.authorSalamone, John
dc.contributor.authorKoychev, Ivan
dc.contributor.authorCorrea, Merce
dc.contributor.authorMcGuire, Philip
dc.date.accessioned2016-06-08T13:02:53Z
dc.date.available2016-06-08T13:02:53Z
dc.date.issued2015
dc.identifier.citationSALAMONE, John D., et al. Neurobiological basis of motivational deficits in psychopathology. European Neuropsychopharmacology, 2015, vol. 25, no 8, p. 1225-1238.ca_CA
dc.identifier.issn0924-977X
dc.identifier.issn1873-7862
dc.identifier.urihttp://hdl.handle.net/10234/160471
dc.description.abstractIn recent years, there has been increasing emphasis on the importance of motivational symptoms in depression, schizophrenia and other disorders. The present review discusses the conceptual background related to the construct of motivation, and provides a framework that for research on both physiological and pathological aspects of motivation. Particular emphasis is placed on what is known about the neurobiological basis of activational aspects of motivation, including studies from animal models. The role of limbic/prefrontal/striatal circuitry in behavioral activation and effort-related functions is examined, and the utility of behavioral tasks of effort-based decision making as models of motivational symptoms is discussed. We also review the neurobiology of motivational symptoms in relation to psychopathology, and issues related to the language used to characterize motivational dysfunctions are considered. The literature suggests that research on the neurobiology of motivational dysfunction in psychopathology, at both clinical and preclinical levels, could inform the development of novel and more effective treatments for a range of CNS disorders.ca_CA
dc.format.extent13 p.ca_CA
dc.format.mimetypeapplication/pdfca_CA
dc.language.isoengca_CA
dc.publisherElsevierca_CA
dc.relation.isPartOfEuropean Neuropsychopharmacology, 2015, vol. 25, no 8, p. 1225-1238ca_CA
dc.rights© 2015 Published by Elsevier Inc.ca_CA
dc.rights.urihttp://rightsstatements.org/vocab/InC/1.0/*
dc.subjectAnticipationca_CA
dc.subjectBehavioural activationca_CA
dc.subjectEffort-based choiceca_CA
dc.subjectMotivationca_CA
dc.titleNeurobiological basis of motivational deficits in psychopathologyca_CA
dc.typeinfo:eu-repo/semantics/articleca_CA
dc.identifier.doihttp://dx.doi.org/10.1016/j.euroneuro.2014.08.014
dc.rights.accessRightsinfo:eu-repo/semantics/restrictedAccessca_CA
dc.relation.publisherVersionhttp://www.europeanneuropsychopharmacology.com/article/S0924-977X(14)00248-X/abstractca_CA
dc.type.versioninfo:eu-repo/semantics/publishedVersionca_CA


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