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dc.contributor.authorSchmid, Jean-Paul
dc.contributor.authorNobel, Daniel
dc.contributor.authorBrugger, Nicolas
dc.contributor.authorPalau, Patricia
dc.contributor.authorTrepp, Anja
dc.contributor.authorWilhelm, Matthias
dc.contributor.authorSaner, Hugo
dc.date.accessioned2016-06-06T12:30:26Z
dc.date.available2016-06-06T12:30:26Z
dc.date.issued2015
dc.identifier.citationSCHMID, Jean‐Paul, et al. Short‐term high altitude exposure at 3454 m is well tolerated in patients with stable heart failure. European journal of heart failure, 2015, vol. 17, no 2, p. 182-186.ca_CA
dc.identifier.issn1388-9842
dc.identifier.issn1879-0844
dc.identifier.urihttp://hdl.handle.net/10234/160373
dc.description.abstractAims High altitude exposure for the purpose of tourism is very popular in mountainous regions and is considered to be safe for patients with stable CAD and preserved LV function. The purpose of this study was to evaluate the haemodynamic response to exercise and electrical stability by Holter monitoring in patients with chronic heart failure (HF) and an EF <40%. Methods and results We studied 29 HF patients with a peak VO2 >50% of the predicted (25 men, age 60.0 ± 8.9 years, EF 28.8 ± 5.4%) at 540 and 3454 m after an ascent using public transport. Assessments of exercise capacity (cardiopulmonary exercise test), haemodynamic response (inert gas rebreathing system), and susceptibility to arrhythmias (Holter ECG recording) were performed. None of the patients (19 with ischaemic heart disease, 11 with an implantable cardioverter defibrillator) had to return prematurely to the lowland site. Two patients presented symptoms of mild mountain sickness, and one patient developed a self-limited ventricular tachycardia during maximal exercise at high altitude. Mean peak VO2 at the lowland site was 18.5 ± 3.6 mL/min/kg and decreased by 22.2% (P < 0.001) at high altitude. Mean resting heart rate increased from 74.3 ± 12.3 to 83.3 ± 13.4 b.p.m., P < 0.001. No statistically significant difference in premature ventricular contractions (92 ± 150/h at 540 m vs. 111 ± 196/h at 3454 m, P = 0.284) was noted. Conclusion Patients with stable chronic HF and a peak VO2 >50% of the predicted tolerate a short exposure to an altitude of 3454 m well, even during exercise. However, it cannot be excluded that the susceptibility to ventricular tachyarrhythmias during exercise is increased in some subjects.ca_CA
dc.format.extent4 p.ca_CA
dc.format.mimetypeapplication/pdfca_CA
dc.language.isoengca_CA
dc.publisherWileyca_CA
dc.relation.isPartOfEuropean Journal of Heart Failure Volume 17, Issue 2, pages 182–186, February 2015ca_CA
dc.rights© 2015 The Authors. European Journal of Heart Failure © 2015 European Society of Cardiologyca_CA
dc.subjectHeart failureca_CA
dc.subjectHigh altitudeca_CA
dc.subjectExercise capacityca_CA
dc.subjectInert gas rebreathingca_CA
dc.titleShort-term high altitude exposure at 3454 m is well tolerated in patients with stable heart failureca_CA
dc.typeinfo:eu-repo/semantics/articleca_CA
dc.identifier.doihttp://dx.doi.org/10.1002/ejhf.227
dc.rights.accessRightsinfo:eu-repo/semantics/restrictedAccessca_CA
dc.relation.publisherVersionhttp://onlinelibrary.wiley.com/doi/10.1002/ejhf.227/abstractca_CA


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