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Inverse association between habitual polyphenol intake and incidence of cardiovascular events in the PREDIMED study
dc.contributor.author | Tresserra-Rimbau, Anna | |
dc.contributor.author | Rimm, Eric B. | |
dc.contributor.author | Medina Remón, A. | |
dc.contributor.author | Martínez González, Miguel Ángel | |
dc.contributor.author | De la Torre, R. | |
dc.contributor.author | Corella, Dolores | |
dc.contributor.author | Salas-Salvadó, Jordi | |
dc.contributor.author | Gómez Gracia, Enrique | |
dc.contributor.author | Lapetra, José | |
dc.contributor.author | Arós, Fernando | |
dc.contributor.author | Fiol Ramis, Miquel | |
dc.contributor.author | Ros, Emilio | |
dc.contributor.author | Serra-Majem, Lluis | |
dc.contributor.author | Pintó, Xavier | |
dc.contributor.author | Sáez Tormo, Guillermo | |
dc.contributor.author | Basora, Josep | |
dc.contributor.author | Sorlí, José V | |
dc.contributor.author | Martínez, J. Alfredo | |
dc.contributor.author | Vinyoles, E. | |
dc.contributor.author | Ruiz-Gutiérrez, Valentina | |
dc.contributor.author | Estruch, Ramon | |
dc.contributor.author | Lamuela Raventós, Rosa María | |
dc.contributor.author | Coltell, Oscar | |
dc.date.accessioned | 2016-06-06T11:38:10Z | |
dc.date.available | 2016-06-06T11:38:10Z | |
dc.date.issued | 2016-06 | |
dc.identifier.citation | TRESSERRA RIMBAU, A.; RIMM, Eric B.; MEDINA REMÓN, A.; MARTÍNEZ GONZÁLEZ, Miguel Ángel; DE LA TORRE, R.; CORELLA, Dolores; SALAS SALVADÓ, Jordi; GÓMEZ GRACIA, Enrique; LAPETRA, José; ARÓS, Fernando; FIOL RAMIS, Miquel; ROS, Emilio; SERRA MAJEM, Lluís; PINTÓ, Xavier; SÁEZ TORMO, Guillermo; BASORA, J.; SORLÍ, José V.; MARTÍNEZ, J. Alfredo; VINYOLES, E.; RUIZ GUTIÉRREZ, Valentina; ESTRUCH RIBA, Ramón; LAMUELA RAVENTÓS, Rosa María; COLTELL SIMÓN, Óscar. Inverse association between habitual polyphenol intake and incidence of cardiovascular events in the PREDIMED study. Nutrition, Metabolism and Cardiovascular Diseases (2016), v. 24, issue 6, pp. 639-647 | ca_CA |
dc.identifier.uri | http://hdl.handle.net/10234/160369 | |
dc.description.abstract | Background and aims Epidemiologic and biological evidence supports an inverse association between polyphenol consumption and the risk of cardiovascular disease (CVD). However, no previous studies have prospectively evaluated the relationship between polyphenol intake and the incidence of CVD in such a comprehensive way. The aim was to evaluate the association between intakes of total polyphenol and polyphenol subgroups, and the risk of major cardiovascular events (myocardial infarction, stroke or death from cardiovascular causes) in the PREDIMED study. Methods and results The present work is an observational study within the PREDIMED trial. Over an average of 4.3 years of follow-up, there were 273 confirmed cases of CVD among the 7172 participants (96.3%) who completed a validated 137-item food frequency questionnaire (FFQ) at baseline. Polyphenol consumption was calculated by matching food consumption data from the FFQ with the Phenol-Explorer database on polyphenol content of each reported food. After multivariate adjustment, a 46% reduction in risk of CVD risk was observed comparing Q5 vs. Q1 of total polyphenol intake (HR = 0.54; 95% confidence interval [CI] = 0.33–0.91; P-trend = 0.04). The polyphenols with the strongest inverse associations were flavanols (HR = 0.40; CI 0.23–0.72; P-trend = 0.003), lignans (HR = 0.51; CI 0.30–0.86; P-trend = 0.007), and hydroxybenzoic acids (HR = 0.47; CI 0.26–0.86; P-trend 0.02). Conclusion Greater intake of polyphenols, especially from lignans, flavanols, and hydroxybenzoic acids, was associated with decreased CVD risk. Clinical trials are needed to confirm this effect and establish accurate dietary recommendations. Clinical trial registry: International Standard Randomized Controlled Trial Number (ISRCTN of London, England) 35739639. | ca_CA |
dc.description.sponsorShip | This study was supported by CICYT (AGL2010-22319-C03) from the Spanish Ministry of Science and Innovation (MICINN), and the Instituto de Salud Carlos III, ISCIII (CIBERobn-CB06/03, PI1002658, and PI1001407). CIBERobn is an initiative of ISCIII, Spain. AT-R received support from ISCIII (FI10/00265). | ca_CA |
dc.format.extent | 9 p. | ca_CA |
dc.format.mimetype | application/pdf | ca_CA |
dc.language.iso | eng | ca_CA |
dc.publisher | Elsevier | ca_CA |
dc.relation.isPartOf | Nutrition, Metabolism and Cardiovascular Diseases (2016), v. 24, issue 6 | ca_CA |
dc.rights.uri | http://rightsstatements.org/vocab/CNE/1.0/ | * |
dc.subject | Polyphenols | ca_CA |
dc.subject | Diet | ca_CA |
dc.subject | Epidemiology | ca_CA |
dc.subject | Cardiovascular diseases | ca_CA |
dc.title | Inverse association between habitual polyphenol intake and incidence of cardiovascular events in the PREDIMED study | ca_CA |
dc.type | info:eu-repo/semantics/article | ca_CA |
dc.identifier.doi | http://dx.doi.org/10.1016/j.numecd.2013.12.014 | |
dc.rights.accessRights | info:eu-repo/semantics/restrictedAccess | ca_CA |
dc.relation.publisherVersion | http://www.sciencedirect.com/science/article/pii/S0939475314000088 | ca_CA |
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