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dc.contributor.authorTresserra-Rimbau, Anna
dc.contributor.authorRimm, Eric B.
dc.contributor.authorMedina Remón, A.
dc.contributor.authorMartínez González, Miguel Ángel
dc.contributor.authorDe la Torre, R.
dc.contributor.authorCorella, Dolores
dc.contributor.authorSalas-Salvadó, Jordi
dc.contributor.authorGómez Gracia, Enrique
dc.contributor.authorLapetra, José
dc.contributor.authorArós, Fernando
dc.contributor.authorFiol Ramis, Miquel
dc.contributor.authorRos, Emilio
dc.contributor.authorSerra-Majem, Lluis
dc.contributor.authorPintó, Xavier
dc.contributor.authorSáez Tormo, Guillermo
dc.contributor.authorBasora, Josep
dc.contributor.authorSorlí, José V
dc.contributor.authorMartínez, J. Alfredo
dc.contributor.authorVinyoles, E.
dc.contributor.authorRuiz-Gutiérrez, Valentina
dc.contributor.authorEstruch, Ramon
dc.contributor.authorLamuela Raventós, Rosa María
dc.contributor.authorColtell, Oscar
dc.date.accessioned2016-06-06T11:38:10Z
dc.date.available2016-06-06T11:38:10Z
dc.date.issued2016-06
dc.identifier.citationTRESSERRA RIMBAU, A.; RIMM, Eric B.; MEDINA REMÓN, A.; MARTÍNEZ GONZÁLEZ, Miguel Ángel; DE LA TORRE, R.; CORELLA, Dolores; SALAS SALVADÓ, Jordi; GÓMEZ GRACIA, Enrique; LAPETRA, José; ARÓS, Fernando; FIOL RAMIS, Miquel; ROS, Emilio; SERRA MAJEM, Lluís; PINTÓ, Xavier; SÁEZ TORMO, Guillermo; BASORA, J.; SORLÍ, José V.; MARTÍNEZ, J. Alfredo; VINYOLES, E.; RUIZ GUTIÉRREZ, Valentina; ESTRUCH RIBA, Ramón; LAMUELA RAVENTÓS, Rosa María; COLTELL SIMÓN, Óscar. Inverse association between habitual polyphenol intake and incidence of cardiovascular events in the PREDIMED study. Nutrition, Metabolism and Cardiovascular Diseases (2016), v. 24, issue 6, pp. 639-647ca_CA
dc.identifier.urihttp://hdl.handle.net/10234/160369
dc.description.abstractBackground and aims Epidemiologic and biological evidence supports an inverse association between polyphenol consumption and the risk of cardiovascular disease (CVD). However, no previous studies have prospectively evaluated the relationship between polyphenol intake and the incidence of CVD in such a comprehensive way. The aim was to evaluate the association between intakes of total polyphenol and polyphenol subgroups, and the risk of major cardiovascular events (myocardial infarction, stroke or death from cardiovascular causes) in the PREDIMED study. Methods and results The present work is an observational study within the PREDIMED trial. Over an average of 4.3 years of follow-up, there were 273 confirmed cases of CVD among the 7172 participants (96.3%) who completed a validated 137-item food frequency questionnaire (FFQ) at baseline. Polyphenol consumption was calculated by matching food consumption data from the FFQ with the Phenol-Explorer database on polyphenol content of each reported food. After multivariate adjustment, a 46% reduction in risk of CVD risk was observed comparing Q5 vs. Q1 of total polyphenol intake (HR = 0.54; 95% confidence interval [CI] = 0.33–0.91; P-trend = 0.04). The polyphenols with the strongest inverse associations were flavanols (HR = 0.40; CI 0.23–0.72; P-trend = 0.003), lignans (HR = 0.51; CI 0.30–0.86; P-trend = 0.007), and hydroxybenzoic acids (HR = 0.47; CI 0.26–0.86; P-trend 0.02). Conclusion Greater intake of polyphenols, especially from lignans, flavanols, and hydroxybenzoic acids, was associated with decreased CVD risk. Clinical trials are needed to confirm this effect and establish accurate dietary recommendations. Clinical trial registry: International Standard Randomized Controlled Trial Number (ISRCTN of London, England) 35739639.ca_CA
dc.description.sponsorShipThis study was supported by CICYT (AGL2010-22319-C03) from the Spanish Ministry of Science and Innovation (MICINN), and the Instituto de Salud Carlos III, ISCIII (CIBERobn-CB06/03, PI1002658, and PI1001407). CIBERobn is an initiative of ISCIII, Spain. AT-R received support from ISCIII (FI10/00265).ca_CA
dc.format.extent9 p.ca_CA
dc.format.mimetypeapplication/pdfca_CA
dc.language.isoengca_CA
dc.publisherElsevierca_CA
dc.relation.isPartOfNutrition, Metabolism and Cardiovascular Diseases (2016), v. 24, issue 6ca_CA
dc.rights.urihttp://rightsstatements.org/vocab/CNE/1.0/*
dc.subjectPolyphenolsca_CA
dc.subjectDietca_CA
dc.subjectEpidemiologyca_CA
dc.subjectCardiovascular diseasesca_CA
dc.titleInverse association between habitual polyphenol intake and incidence of cardiovascular events in the PREDIMED studyca_CA
dc.typeinfo:eu-repo/semantics/articleca_CA
dc.identifier.doihttp://dx.doi.org/10.1016/j.numecd.2013.12.014
dc.rights.accessRightsinfo:eu-repo/semantics/restrictedAccessca_CA
dc.relation.publisherVersionhttp://www.sciencedirect.com/science/article/pii/S0939475314000088ca_CA


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