On the different sources of cooperativity in pH titrating sites of a membrane protein channel
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http://dx.doi.org/10.1140/epje/i2016-16029-2 |
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Títol
On the different sources of cooperativity in pH titrating sites of a membrane protein channelData de publicació
2016Editor
EDP Sciences; Società Italiana di Fisica; Springer-VerlagISSN
1292-8941; 1292-895XCita bibliogràfica
ALCARAZ, Antonio; QUERALT-MARTÍN, María. On the different sources of cooperativity in pH titrating sites of a membrane protein channel. The European Physical Journal E, 2016, vol. 39, no 3, p. 1-6.Tipus de document
info:eu-repo/semantics/articleVersió de l'editorial
http://link.springer.com/article/10.1140%2Fepje%2Fi2016-16029-2Versió
info:eu-repo/semantics/publishedVersionParaules clau / Matèries
Resum
Cooperative interactions play a central role in the regulation of protein functions. Here we show that in multi-site systems like ion channels the application of the Hill formalism could require a combination of ... [+]
Cooperative interactions play a central role in the regulation of protein functions. Here we show that in multi-site systems like ion channels the application of the Hill formalism could require a combination of different experiments, even involving site-directed mutagenesis, to identify the different sources of cooperativity and to discriminate between genuine and apparent cooperativity. We discuss the implications for the channel function in the bacterial porins PorA (N. meningitidis) and OmpF (E. coli) and the viroporin SARS-CoV E. [-]
Publicat a
The European Physical Journal E, 2016, vol. 39, no 3Drets d'accés
© EDP Sciences / Società Italiana di Fisica / Springer-Verlag
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info:eu-repo/semantics/restrictedAccess
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