Highly sensitive and ultrafast read mapping for RNA-seq analysis
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Otros documentos de la autoría: Barrachina Mir, Sergio; Castillo Catalán, María Isabel; Martínez Pérez, Héctor; Medina, Ignacio; Tárraga, Joaquín; Quintana-Orti, Enrique S.; Dopazo, Joaquín; Salavert Torres, José; Blanquer Espert, Ignacio; Paschall, J.; Hernández-García, V.
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INVESTIGACIONMetadatos
Título
Highly sensitive and ultrafast read mapping for RNA-seq analysisAutoría
Fecha de publicación
2016Editor
Oxford University PressISSN
1340-2838; 1756-1663Cita bibliográfica
I. Medina, J. Tárraga, H. Martínez, S. Barrachina, M. I. Castillo, J. Paschall, J. Salavert-Torres, I. Blanquer-Espert, V. Hernández-García, E. S. Quintana-Ortí, and J. Dopazo. Highly sensitive and ultrafast read mapping for RNA-seq analysis DNA Res first published online January 5, 2016 doi:10.1093/dnares/dsv039Tipo de documento
info:eu-repo/semantics/articleVersión de la editorial
http://dnaresearch.oxfordjournals.org/content/early/2016/01/05/dnares.dsv039.ful ...Palabras clave / Materias
Resumen
As sequencing technologies progress, the amount of data produced grows exponentially, shifting
the bottleneck of discovery towards the data analysis phase. In particular, currently available mapping
solutions for ... [+]
As sequencing technologies progress, the amount of data produced grows exponentially, shifting
the bottleneck of discovery towards the data analysis phase. In particular, currently available mapping
solutions for RNA-seq leave room for improvement in terms of sensitivity and performance, hindering
an efficient analysis of transcriptomes by massive sequencing. Here, we present an
innovative approach that combines re-engineering, optimization and parallelization. This solution results
in a significant increase of mapping sensitivity over a wide range of read lengths and substantial
shorter runtimes when compared with current RNA-seq mapping methods available. [-]
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info:eu-repo/semantics/openAccess
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