Septal projections to the nucleus incertus in the rat: Bidirectional pathways for modulation of hippocampal function
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Otros documentos de la autoría: Sánchez-Pérez, Ana María; Arnal Vicente, Isabel; Santos, F. N.; Pereira, C. W.; El Mlili, Nisrin; Sanjuán, Julio; Ma, Sherie; Gundlach, Andrew Lawrence; Olucha-Bordonau, Francisco E
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Título
Septal projections to the nucleus incertus in the rat: Bidirectional pathways for modulation of hippocampal functionAutoría
Fecha de publicación
2015-03Editor
WileyCita bibliográfica
SÁNCHEZ‐PÉREZ, Ana M., et al. Septal projections to nucleus incertus in the rat: bidirectional pathways for modulation of hippocampal function. Journal of Comparative Neurology, 2015, vol. 523, no 4, p. 565-588.Tipo de documento
info:eu-repo/semantics/articleVersión de la editorial
http://onlinelibrary.wiley.com/doi/10.1002/cne.23687/fullVersión
info:eu-repo/semantics/acceptedVersionPalabras clave / Materias
Resumen
Projections from the nucleus incertus (NI) to the septum have been implicated in the modulation of hippocampal theta rhythm. In this study we describe a previously uncharacterized projection from the septum to the NI, ... [+]
Projections from the nucleus incertus (NI) to the septum have been implicated in the modulation of hippocampal theta rhythm. In this study we describe a previously uncharacterized projection from the septum to the NI, which may provide feedback modulation of the ascending circuitry. Fluorogold injections into the NI resulted in retrograde labeling in the septum that was concentrated in the horizontal diagonal band and areas of the posterior septum including the septofimbrial and triangular septal nuclei. Double-immunofluorescent staining indicated that the majority of NI-projecting septal neurons were calretinin-positive and some were parvalbumin-, calbindin-, or glutamic acid decarboxylase (GAD)−67-positive. Choline acetyltransferase-positive neurons were Fluorogold-negative. Injection of anterograde tracers into medial septum, or triangular septal and septofimbrial nuclei, revealed fibers descending to the supramammillary nucleus, median raphe, and the NI. These anterogradely labeled varicosities displayed synaptophysin immunoreactivity, indicating septal inputs form synapses on NI neurons. Anterograde tracer also colocalized with GAD-67-positive puncta in labeled fibers, which in some cases made close synaptic contact with GAD-67-labeled NI neurons. These data provide evidence for the existence of an inhibitory descending projection from medial and posterior septum to the NI that provides a "feedback loop" to modulate the comparatively more dense ascending NI projections to medial septum and hippocampus. Neural processes and associated behaviors activated or modulated by changes in hippocampal theta rhythm may depend on reciprocal connections between ascending and descending pathways rather than on unidirectional regulation via the medial septum. [-]
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Journal of Comparative Neurology Volume 523, Issue 4, March 2015Derechos de acceso
© 2014 Wiley Periodicals, Inc.
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info:eu-repo/semantics/openAccess
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