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dc.contributor.authorLópez-Pedrajas, Rosa
dc.contributor.authorRamírez Lamelas, Dolores T.
dc.contributor.authorMuriach, Borja
dc.contributor.authorSánchez-Villarejo, María V.
dc.contributor.authorAlmansa, Inmaculada
dc.contributor.authorVidal Gil, Lorena
dc.contributor.authorRomero, Francisco J.
dc.contributor.authorBarcia, Jorge M
dc.contributor.authorMuriach Saurí, María
dc.date.accessioned2016-04-26T13:40:51Z
dc.date.available2016-04-26T13:40:51Z
dc.date.issued2015
dc.identifier.citationLÓPEZ-PEDRAJAS, Rosa, et al. Cocaine promotes oxidative stress and microglial-macrophage activation in rat cerebellum. Frontiers in cellular neuroscience, 2015, vol. 9.ca_CA
dc.identifier.issn1662-5102
dc.identifier.urihttp://hdl.handle.net/10234/158964
dc.description.abstractDifferent mechanisms have been suggested for cocaine neurotoxicity, including oxidative stress alterations. Nuclear factor kappa B (NF-κB), considered a sensor of oxidative stress and inflammation, is involved in drug toxicity and addiction. NF-κB is a key mediator for immune responses that induces microglial/macrophage activation under inflammatory processes and neuronal injury/degeneration. Although cerebellum is commonly associated to motor control, muscular tone, and balance. Its relation with addiction is getting relevance, being associated to compulsive and perseverative behaviors. Some reports indicate that cerebellar microglial activation induced by cannabis or ethanol, promote cerebellar alterations and these alterations could be associated to addictive-related behaviors. After considering the effects of some drugs on cerebellum, the aim of the present work analyzes pro-inflammatory changes after cocaine exposure. Rats received daily 15 mg/kg cocaine i.p., for 18 days. Reduced and oxidized forms of glutathione (GSH) and oxidized glutathione (GSSG), glutathione peroxidase (GPx) activity and glutamate were determined in cerebellar homogenates. NF-κB activity, CD68, and GFAP expression were determined. Cerebellar GPx activity and GSH/GSSG ratio are significantly decreased after cocaine exposure. A significant increase of glutamate concentration is also observed. Interestingly, increased NF-κB activity is also accompanied by an increased expression of the lysosomal mononuclear phagocytic marker ED1 without GFAP alterations. Current trends in addiction biology are focusing on the role of cerebellum on addictive behaviors. Cocaine-induced cerebellar changes described herein fit with previosus data showing cerebellar alterations on addict subjects and support the proposed role of cerebelum in addiction.ca_CA
dc.format.extent10 p.ca_CA
dc.format.mimetypeapplication/pdfca_CA
dc.language.isoengca_CA
dc.publisherFrontiers Mediaca_CA
dc.relation.isPartOfFront. Cell. Neurosci., 28 July 2015ca_CA
dc.rightsThis Document is Protected by copyright and was first published by Frontiers. All rights reserved. it is reproduced with permission. Copyright © 2015 López-Pedrajas, Ramírez-Lamelas, Muriach, Sánchez-Villarejo, Almansa, Vidal-Gil, Romero, Barcia and Muriach. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.ca_CA
dc.rightsAttribution 4.0 Spain*
dc.rights.urihttp://creativecommons.org/licenses/by-sa/4.0/*
dc.subjectCerebellumca_CA
dc.subjectCocaineca_CA
dc.subjectNuclear factor kappa Bca_CA
dc.subjectOxidative stressca_CA
dc.subjectMononuclear phagocyteca_CA
dc.titleCocaine promotes oxidative stress and microglial-macrophage activation in rat cerebellumca_CA
dc.typeinfo:eu-repo/semantics/articleca_CA
dc.identifier.doihttp://dx.doi.org/10.3389/fncel.2015.00279
dc.rights.accessRightsinfo:eu-repo/semantics/openAccessca_CA
dc.relation.publisherVersionhttp://journal.frontiersin.org/article/10.3389/fncel.2015.00279/fullca_CA
dc.type.versioninfo:eu-repo/semantics/publishedVersion


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This Document is Protected by copyright and was first published by Frontiers. All rights reserved. it is reproduced with permission. 
Copyright © 2015 López-Pedrajas, Ramírez-Lamelas, Muriach, Sánchez-Villarejo, Almansa, Vidal-Gil, Romero, Barcia and Muriach. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
Excepto si se señala otra cosa, la licencia del ítem se describe como: This Document is Protected by copyright and was first published by Frontiers. All rights reserved. it is reproduced with permission. Copyright © 2015 López-Pedrajas, Ramírez-Lamelas, Muriach, Sánchez-Villarejo, Almansa, Vidal-Gil, Romero, Barcia and Muriach. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.