Mostrar el registro sencillo del ítem

Synthetic studies on the preparation of alanyl epoxysulfones as cathepsin cysteine protease electrophilic traps

dc.contributor.authorLatorre, Antonio
dc.contributor.authorRodríguez, Santiago
dc.contributor.authorGonzález, Florenci
dc.contributor.authorFlorea, Bogdan I.
dc.contributor.authorOverkleeft, Herman S.
dc.date.accessioned2016-04-14T10:46:49Z
dc.date.available2016-04-14T10:46:49Z
dc.date.issued2015-07
dc.identifier.citationLATORRE, Antonio, et al. Synthetic Studies on the Preparation of Alanyl Epoxysulfones as Cathepsin Cysteine Protease Electrophilic Traps. The Journal of organic chemistry, 2015, vol. 80, no 15, p. 7752-7756.ca_CA
dc.identifier.urihttp://hdl.handle.net/10234/158585
dc.description.abstractA Darzens reaction between tert-butoxycarbonyl alaninal and chloromethyl phenyl sulfone afforded chlorohydrins, which were converted into epoxysulfones by reaction with sodium tert-butoxide. Epoxysulfone 10 and chloroketone 14 derived from chlorohydrins by oxidation proved to be inhibitors of cathepsins H, S, and C as determined by competitive activity-based protein profiling.ca_CA
dc.format.extent4 p.ca_CA
dc.format.mimetypeapplication/pdfca_CA
dc.language.isoengca_CA
dc.publisherAmerican Chemical Societyca_CA
dc.relation.isPartOfJ. Org. Chem., 2015, 80 (15)ca_CA
dc.rightsCopyright © 2015, American Chemical Societyca_CA
dc.rights.urihttp://rightsstatements.org/vocab/InC/1.0/*
dc.subjectCysteine Proteasesca_CA
dc.subjectEpoxysulfonesca_CA
dc.subjectAlanineca_CA
dc.subjectChloromethylca_CA
dc.subjectCathepsinca_CA
dc.titleSynthetic studies on the preparation of alanyl epoxysulfones as cathepsin cysteine protease electrophilic trapsca_CA
dc.typeinfo:eu-repo/semantics/articleca_CA
dc.identifier.doihttp://dx.doi.org/10.1021/acs.joc.5b01013
dc.rights.accessRightsinfo:eu-repo/semantics/restrictedAccessca_CA
dc.relation.publisherVersionhttp://pubs.acs.org/doi/abs/10.1021/acs.joc.5b01013ca_CA


Ficheros en el ítem

FicherosTamañoFormatoVer

No hay ficheros asociados a este ítem.

Este ítem aparece en la(s) siguiente(s) colección(ones)

Mostrar el registro sencillo del ítem