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dc.contributor.authorNieto Torres, José L.
dc.contributor.authorVerdiá Báguena, Carmen
dc.contributor.authorCastaño Rodríguez, Carlos
dc.contributor.authorAguilella, Vicente
dc.contributor.authorEnjuanes, Luis
dc.date.accessioned2016-03-14T09:48:23Z
dc.date.available2016-03-14T09:48:23Z
dc.date.issued2015-07
dc.identifier.citationNIETO-TORRES, Jose L., et al. Relevance of viroporin ion channel activity on viral replication and pathogenesis. Viruses, 2015, vol. 7, no 7, p. 3552-3573.ca_CA
dc.identifier.urihttp://hdl.handle.net/10234/153566
dc.description.abstractModification of host-cell ionic content is a significant issue for viruses, as several viral proteins displaying ion channel activity, named viroporins, have been identified. Viroporins interact with different cellular membranes and self-assemble forming ion conductive pores. In general, these channels display mild ion selectivity, and, eventually, membrane lipids play key structural and functional roles in the pore. Viroporins stimulate virus production through different mechanisms, and ion channel conductivity has been proved particularly relevant in several cases. Key stages of the viral cycle such as virus uncoating, transport and maturation are ion-influenced processes in many viral species. Besides boosting virus propagation, viroporins have also been associated with pathogenesis. Linking pathogenesis either to the ion conductivity or to other functions of viroporins has been elusive for a long time. This article summarizes novel pathways leading to disease stimulated by viroporin ion conduction, such as inflammasome driven immunopathology.ca_CA
dc.format.extent19 p.ca_CA
dc.format.mimetypeapplication/pdfca_CA
dc.language.isoengca_CA
dc.publisherMDPIca_CA
dc.relation.isPartOfViruses, 2015, vol. 7, no 7ca_CA
dc.rights© 2015 by the authors; licensee MDPI, Basel, Switzerland.ca_CA
dc.rightsAttribution 4.0 Spain*
dc.rights.urihttp://creativecommons.org/licenses/by-sa/4.0/*
dc.subjectviroporinsca_CA
dc.subjectvirusca_CA
dc.subjection channelca_CA
dc.subjectprotein-lipid poreca_CA
dc.subjecteplicationca_CA
dc.subjectpathogenesisca_CA
dc.subjectinflammasomeca_CA
dc.titleRelevance of Viroporin Ion Channel Activity on Viral Replication and Pathogenesisca_CA
dc.typeinfo:eu-repo/semantics/articleca_CA
dc.identifier.doihttp://dx.doi.org/10.3390/v7072786
dc.rights.accessRightsinfo:eu-repo/semantics/openAccessca_CA
dc.relation.publisherVersionhttp://www.mdpi.com/1999-4915/7/7/2786/htmca_CA
dc.type.versioninfo:eu-repo/semantics/publishedVersion


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© 2015 by the authors; licensee MDPI, Basel, Switzerland.
Excepto si se señala otra cosa, la licencia del ítem se describe como: © 2015 by the authors; licensee MDPI, Basel, Switzerland.