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dc.contributor.authorNavarrete Muñoz, Eva María
dc.contributor.authorValera-Gran, Desirée
dc.contributor.authorGarcía de la Hera, Manuela
dc.contributor.authorGiménez Monzó, Daniel
dc.contributor.authorMorales, Eva
dc.contributor.authorJulvez, Jordi
dc.contributor.authorRiaño, Isolina
dc.contributor.authorTardon, Adonina
dc.contributor.authorIbarluzea, Jesus
dc.contributor.authorSanta Marina, Loreto
dc.contributor.authorMurcia, Mario
dc.contributor.authorRebagliato, Marisa
dc.contributor.authorVioque, Jesús
dc.identifier.citationNAVARRETE-MUÑOZ, Eva María, et al. Use of high doses of folic acid supplements in pregnant women in Spain: an INMA cohort study. BMJ open, 2015, vol. 5, no 11, p. e009202.ca_CA
dc.description.abstractObjectives: We examined the use of low (<400 μg/day, including no use) and high folic acid supplement (FAS) dosages (≥1000 μg/day) among pregnant women in Spain, and explored factors associated with the use of these non-recommended dosages. Design: Population-based cohort study. Setting Spain. Participants We analysed data from 2332 pregnant women of the INMA study, a prospective mother-child cohort study in Spain. Main outcome measures We assessed usual dietary folate and the use of FAS from preconception to the 3rd month (first period) and from the 4th to the 7th month (second period), using a validated food frequency questionnaire. We used multinomial logistic regression to estimate relative risk ratios (RRRs). Results Over a half of the women used low dosages of FAS in the first and second period while 29% and 17% took high dosages of FAS, respectively. In the first period, tobacco smoking (RRR=1.63), alcohol intake (RRR=1.40), multiparous (RRR=1.44), unplanned pregnancy (RRR=4.20) and previous spontaneous abortion (RRR=0.58, lower use of high FAS dosages among those with previous abortions) were significantly associated with low FAS dosages. Alcohol consumption (RRR=1.42), unplanned pregnancy (RRR=2.66) and previous spontaneous abortion (RRR=0.68) were associated with high dosage use. In the second period, only tobacco smoking was significantly associated with high FAS dosage use (RRR=0.67). Conclusions A high proportion of pregnant women did not reach the recommended dosages of FAS in periconception and a considerable proportion also used FAS dosages ≥1000 μg/day. Action should be planned by the Health Care System and health professionals to improve the appropriate periconceptional use of FAS, taking into consideration the associated factors.ca_CA
dc.description.sponsorShipThis study was funded by grants from Instituto de Salud Carlos III and Spanish Ministry of Health (Red INMA G03/176; CB06/02/0041; FIS 97/0588; 00/0021–2, PI061756; PS0901958; FIS-FEDER 03/1615, 04/1509, 04/1112, 04/1931, 05/1079, 05/1052, 06/1213, 07/0314; 09/02647; FIS-PI041436, FIS-PI081151, FIS-PI06/0867; FIS-PS09/00090, FIS-PI042018, FIS-PI09 02311, FIS PI11/01007, FISPI13/02429) Universidad de Oviedo, Conselleria de Sanitat Generalitat Valenciana, Generalitat de Catalunya-CIRIT 1999SGR 00241, Department of Health of the Basque Government (2005111093 and 2009111069) and the Provincial Government of Guipuzcoa (DFG06/004 and DFG08/001).ca_CA
dc.format.extent9 p.ca_CA
dc.publisherBMJ Publishing Groupca_CA
dc.relation.isPartOfBMJ open, 2015, vol. 5, no 11ca_CA
dc.rightsCopyright © by the BMJ Publishing Groupca_CA
dc.rightsAttribution-NonCommercial 3.0 Spain*
dc.subjectnutrition & dieteticsca_CA
dc.subjectpublic healthca_CA
dc.titleUse of high doses of folic acid supplements in pregnant women in Spain: an INMA cohort studyca_CA
dc.identifier.doi 10.1136/bmjopen-2015-009202

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