The Mechanism of the Interactions of Pironetin Analog/Combretastatin A-4 Hybrids with Tubulin
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Otros documentos de la autoría: Torijano Gutiérrez, Sandra Adela; Vilanova Gallén, Concepción; Diaz-Oltra, Santiago; Murga, Juan; Falomir, Eva; Carda, Miguel; Redondo Horcajo, Mariano; Fernando Díaz, J.; Barasoain, Isabel; Marco, J. Alberto
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http://dx.doi.org/10.1002/ardp.201500106 |
Metadatos
Título
The Mechanism of the Interactions of Pironetin Analog/Combretastatin A-4 Hybrids with TubulinAutoría
Fecha de publicación
2015-06-17Editor
WileyISSN
0365-6233Cita bibliográfica
TORIJANO‐GUTIÉRREZ, Sandra, et al. The Mechanism of the Interactions of Pironetin Analog/Combretastatin A‐4 Hybrids with Tubulin. Archiv der Pharmazie, 2015, vol. 348, no 8, p. 541-547.Tipo de documento
info:eu-repo/semantics/articleVersión de la editorial
http://onlinelibrary.wiley.com/doi/10.1002/ardp.201500106/fullPalabras clave / Materias
Resumen
We here report an investigation of the interactions with tubulin of two types of molecules of a hybrid structural type consisting in a combretastatin A-4 moiety and a simplified pironetin fragment. The cytotoxicities ... [+]
We here report an investigation of the interactions with tubulin of two types of molecules of a hybrid structural type consisting in a combretastatin A-4 moiety and a simplified pironetin fragment. The cytotoxicities of the molecules on two reference tumoral cell lines were measured. In addition, the effects of the compounds on the cell cycle and on microtubule assembly were observed. The dynamics of microtubule polymerization was investigated by means of immunofluorescence assays. It was thus established that at least some of the compounds under study exert their cytotoxic action by means of interaction with tubulin. [-]
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Archiv der Pharmazie, 2015, vol. 348, no 8Derechos de acceso
© 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
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