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dc.contributor.authorMcCall, Ann-Kathrin
dc.contributor.authorBade, Richard
dc.contributor.authorKinyua, Juliet
dc.contributor.authorLai, Foon Yin
dc.contributor.authorThai, Phong K.
dc.contributor.authorCovaci, Adrian
dc.contributor.authorBijlsma, Lubertus
dc.contributor.authorVan Nuijs, Alexander L. N.
dc.contributor.authorOrt, Christoph
dc.date.accessioned2016-01-25T10:04:25Z
dc.date.available2016-01-25T10:04:25Z
dc.date.issued2015-10
dc.identifier.citationMcCall, A. K., Bade, R., Kinyua, J., Lai, F. Y., Thai, P. K., Covaci, A., ... & Ort, C. (2016). Critical review on the stability of illicit drugs in sewers and wastewater samples. Water research, 88, 933-947.ca_CA
dc.identifier.urihttp://hdl.handle.net/10234/146505
dc.description.abstractWastewater-based epidemiology (WBE) applies advanced analytical methods to quantify drug residues in wastewater with the aim to estimate illicit drug use at the population level. Transformation processes during transport in sewers (chemical and biological reactors) and storage of wastewater samples before analysis are expected to change concentrations of different drugs to varying degrees. Ignoring transformation for drugs with low to medium stability will lead to an unknown degree of systematic under- or overestimation of drug use, which should be avoided. This review aims to summarize the current knowledge related to the stability of commonly investigated drugs and, furthermore, suggest a more effective approach to future experiments. From over 100 WBE studies, around 50 mentioned the importance of stability and 24 included tests in wastewater. Most focused on in-sample stability (i.e., sample preparation, preservation and storage) and some extrapolated to in-sewer stability (i.e., during transport in real sewers). While consistent results were reported for rather stable compounds (e.g., MDMA and methamphetamine), a varying range of stability under different or similar conditions was observed for other compounds (e.g., cocaine, amphetamine and morphine). Wastewater composition can vary considerably over time, and different conditions prevail in different sewer systems. In summary, this indicates that more systematic studies are needed to: i) cover the range of possible conditions in sewers and ii) compare results more objectively. To facilitate the latter, we propose a set of parameters that should be reported for in-sewer stability experiments. Finally, a best practice of sample collection, preservation, and preparation before analysis is suggested in order to minimize transformation during these steps.ca_CA
dc.format.extent14 p.ca_CA
dc.format.mimetypeapplication/pdfca_CA
dc.language.isoengca_CA
dc.publisherElsevierca_CA
dc.relation.isPartOfWater Research Volume 88, 1 January 2016ca_CA
dc.rightsCopyright © 2015 Elsevier Ltd. All rights reserved.ca_CA
dc.subjectTransformationca_CA
dc.subjectSewage epidemiologyca_CA
dc.subjectSample preservationca_CA
dc.subjectPsychoactive substancesca_CA
dc.subjectBiodegradationca_CA
dc.titleCritical review on the stability of illicit drugs in sewers and wastewater samplesca_CA
dc.typeinfo:eu-repo/semantics/articleca_CA
dc.identifier.doihttp://dx.doi.org/10.1016/j.watres.2015.10.040
dc.rights.accessRightsinfo:eu-repo/semantics/openAccessca_CA
dc.relation.publisherVersionhttp://www.sciencedirect.com/science/article/pii/S0043135415303055ca_CA


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