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dc.contributor.authorCastillo, Nancy I.
dc.contributor.authorIbáñez, Maria
dc.contributor.authorBeltrán Iturat, Eduardo
dc.contributor.authorRivera Monroy, Jhon
dc.contributor.authorOchoa, Juan Camilo
dc.contributor.authorPáez Castillo, Mónica
dc.contributor.authorPosada Buitrago, Martha L.
dc.contributor.authorSulyok, Michael
dc.contributor.authorHernandez, Felix
dc.date.accessioned2016-01-11T10:19:31Z
dc.date.available2016-01-11T10:19:31Z
dc.date.issued2016-01
dc.identifier.citationCASTILLO, Nancy I., et al. Identification of mycotoxins by UHPLC–QTOF MS in airborne fungi and fungi isolated from industrial paper and antique documents from the Archive of Bogotá. Environmental research, 2016, vol. 144, p. 130-138.ca_CA
dc.identifier.urihttp://hdl.handle.net/10234/144665
dc.description.abstractMold deterioration of historical documents in archives and libraries is a frequent and complex phenomenon that may have important economic and cultural consequences. In addition, exposure to toxic fungal metabolites might produce health problems. In this work, samples of broths of fungal species isolated from the documentary material and from indoor environmental samples of the Archive of Bogotá have been analyzed to investigate the presence of mycotoxins. High resolution mass spectrometry made possible to search for a large number of mycotoxins, even without reference standards available at the laboratory. For this purpose, a screening strategy based on ultra-high pressure liquid chromatography coupled to quadrupole-time of flight mass spectrometry (UHPLC–QTOF MS) under MSE mode was applied. A customized home-made database containing elemental composition for around 600 mycotoxins was compiled. The presence of the (de)protonated molecule measured at its accurate mass was evaluated in the samples. When a peak was detected, collision induced dissociation fragments and characteristic isotopic ions were also evaluated and used for tentative identification, based on structure compatibility and comparison with literature data (if existing). Up to 44 mycotoxins were tentatively identified by UHPLC–QTOF MS. 34 of these tentative compounds were confirmed by subsequent analysis using a targeted LC–MS/MS method, supporting the strong potential of QTOF MS for identification/elucidation purposes. The presence of mycotoxins in these samples might help to reinforce safety measures for researchers and staff who work on reception, restoration and conservation of archival material, not only at the Archive of Bogotá but worldwide.ca_CA
dc.description.sponsorShipGeneralitat Valenciana (research group of excellence PROMETEO II/2014/023; ISIC 2012/016), from Alcaldía Mayor de Bogotá (Special Agreement on Cooperation in Science and Technology No. 2215100-153-2013) and from Universidad Antonio Nariño Grant 2010246.
dc.format.extent9 p.ca_CA
dc.format.mimetypeapplication/pdfca_CA
dc.language.isoengca_CA
dc.publisherElsevierca_CA
dc.relation.isPartOfEnvironmental research, 2016, vol. 144ca_CA
dc.rightsCopyright © 2015 Elsevier Inc. All rights reserved.ca_CA
dc.rights.urihttp://rightsstatements.org/vocab/InC/1.0/*
dc.subjectLiquid chromatographyca_CA
dc.subjectQuadrupole time-of-flight mass spectrometryca_CA
dc.subjectFungica_CA
dc.subjectMycotoxinsca_CA
dc.subjectScreeningca_CA
dc.titleIdentification of mycotoxins by UHPLC–QTOF MS in airborne fungi and fungi isolated from industrial paper and antique documents from the Archive of Bogotáca_CA
dc.typeinfo:eu-repo/semantics/articleca_CA
dc.identifier.doihttp://dx.doi.org/10.1016/j.envres.2015.10.031
dc.rights.accessRightsinfo:eu-repo/semantics/openAccessca_CA
dc.relation.publisherVersionhttp://www.sciencedirect.com/science/article/pii/S0013935115301298ca_CA
dc.type.versioninfo:eu-repo/semantics/submittedVersion


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