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dc.contributor.authorCervera, Javier
dc.contributor.authorAlcaraz, Antonio
dc.contributor.authorMafé, Salvador
dc.identifier.citationCERVERA, Javier; ALCARAZ, Antonio; MAFE, Salvador. Membrane Potential Bistability in Nonexcitable Cells as Described by Inward and Outward Voltage-Gated Ion Channels. The Journal of Physical Chemistry B, 2014, 118.43: 12444-12450.ca_CA
dc.description.abstractThe membrane potential of nonexcitable cells, defined as the electrical potential difference between the cell cytoplasm and the extracellular environment when the current is zero, is controlled by the individual electrical conductance of different ion channels. In particular, inward- and outward-rectifying voltage-gated channels are crucial for cell hyperpolarization/depolarization processes, being amenable to direct physical study. High (in absolute value) negative membrane potentials are characteristic of terminally differentiated cells, while low membrane potentials are found in relatively depolarized, more plastic cells (e.g., stem, embryonic, and cancer cells). We study theoretically the hyperpolarized and depolarized values of the membrane potential, as well as the possibility to obtain a bistability behavior, using simplified models for the ion channels that regulate this potential. The bistability regions, which are defined in the multidimensional state space determining the cell state, can be relevant for the understanding of the different model cell states and the transitions between them, which are triggered by changes in the external environment.ca_CA
dc.format.extent6 p.ca_CA
dc.publisherAmerican Chemical Societyca_CA
dc.relation.isPartOfPhys. Chem. B, 2014, 118 (43)ca_CA
dc.rightsCopyright © 2014 American Chemical Societyca_CA
dc.subjectmembrane potentialsca_CA
dc.subjectnon-excitable cellsca_CA
dc.subjectvoltage gated ion channelsca_CA
dc.titleMembrane Potential Bistability in Nonexcitable Cells as Described by Inward and Outward Voltage-Gated Ion Channelsca_CA

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