Design and Synthesis of Pironetin Analogue/Combretastatin A-4 Hybrids and Evaluation of Their Cytotoxic Activity
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Other documents of the author: Torijano Gutiérrez, Sandra Adela; Vilanova Gallén, Concepción; Diaz-Oltra, Santiago; Murga, Juan; Falomir, Eva; Carda, Miguel; Marco, J. Alberto
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Show full item recordcomunitat-uji-handle:10234/9
comunitat-uji-handle2:10234/7053
comunitat-uji-handle3:10234/8639
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Title
Design and Synthesis of Pironetin Analogue/Combretastatin A-4 Hybrids and Evaluation of Their Cytotoxic ActivityAuthor (s)
Date
2014Publisher
Wiley Online LibraryISSN
1434-193XType
info:eu-repo/semantics/articleSubject
Abstract
We describe the preparation of a series of hybrid molecules containing a combretastatin A-4 moiety and a pironetin analogue fragment linked by an ester spacer of variable length. The cytotoxic activities of these ... [+]
We describe the preparation of a series of hybrid molecules containing a combretastatin A-4 moiety and a pironetin analogue fragment linked by an ester spacer of variable length. The cytotoxic activities of these compounds have been measured and the relationship between the structure and cytotoxicity is discussed. Some of the tested compounds showed cytotoxicity values of the same order of magnitude as those of the parental molecules, combretastatin A-4 and pironetin, and were less toxic than the latter for normal cells. [-]
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European Journal of Organic Chemistry, 2014(11)Rights
This is the pre-peer reviewed version of the following article: Torijano‐Gutiérrez, S., Vilanova, C., Díaz‐Oltra, S., Murga, J., Falomir, E., Carda, M., & Marco, J. A. (2014). Design and Synthesis of Pironetin Analogue/Combretastatin A‐4 Hybrids and Evaluation of Their Cytotoxic Activity. European Journal of Organic Chemistry, 2014(11), 2284-2296.
which has been published in final form at [http://onlinelibrary.wiley.com/doi/10.1002/ejoc.201301725/full]
http://rightsstatements.org/vocab/InC/1.0/
info:eu-repo/semantics/openAccess
http://rightsstatements.org/vocab/InC/1.0/
info:eu-repo/semantics/openAccess
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