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dc.contributor.authorTena Solsona, Marta
dc.contributor.authorAlonso de Castro, S.
dc.contributor.authorMiravet, Juan F.
dc.contributor.authorEscuder, Beatriu
dc.date.accessioned2015-07-09T11:00:15Z
dc.date.available2015-07-09T11:00:15Z
dc.date.issued2014-07
dc.identifier.citationTENA-SOLSONA, M., et al. Co-assembly of tetrapeptides into complex pH-responsive molecular hydrogel networks. Journal of Materials Chemistry B, 2014, 2.37: 6192-6197.ca_CA
dc.identifier.urihttp://hdl.handle.net/10234/127005
dc.description.abstractHere we prepare pH-responsive complex molecular hydrogels from oppositely charged tetrapeptidic components that can be pH-tuned resulting in interconversion between different networks. Two different systems are described based on tetrapeptides with an alternating sequence of non-polar (F) and polar (D or K) residues. Co-aggregated hydrogels are easily formed in situ at neutral pH whereas one-component networks are maintained after changing into acidic or basic pH. These systems have been applied for the pH selective release of two hydrophobic dyes – Methylene Blue and Bromothymol Blue – as drug models. Different release profiles have been observed depending on the characteristics of the network as well as the pH of the media. These materials offer great potential as multidrug carriers.ca_CA
dc.format.extent5 p.ca_CA
dc.format.mimetypeapplication/pdfca_CA
dc.language.isoengca_CA
dc.publisherRoyal Society of Chemistryca_CA
dc.relation.isPartOfJournal of Materials Chemistry B, 2014, 2.37ca_CA
dc.rights© The Royal Society of Chemistry 2014ca_CA
dc.subjecttetrapeptidesca_CA
dc.subjectpH-responsiveca_CA
dc.subjectcomplex molecular hydrogelsca_CA
dc.titleCo-assembly of tetrapeptides into complex pH-responsive molecular hydrogel networksca_CA
dc.typeinfo:eu-repo/semantics/articleca_CA
dc.identifier.doihttp://dx.doi.org/10.1039/C4TB00795F
dc.rights.accessRightsinfo:eu-repo/semantics/openAccessca_CA
dc.relation.publisherVersionhttp://pubs.rsc.org/en/Content/ArticleLanding/2014/TB/C4TB00795F#!divAbstractca_CA


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