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dc.contributor.authorStopper, Colin M.
dc.contributor.authorWorden, Lila T.
dc.contributor.authorMingote, Susana
dc.contributor.authorPort, Russell G.
dc.contributor.authorSalamone, John
dc.contributor.authorFont Hurtado, Laura
dc.contributor.authorPereira, Mariana
dc.contributor.authorFarrar, Andrew M.
dc.date.accessioned2010-05-17T07:34:02Z
dc.date.available2010-05-17T07:34:02Z
dc.date.issued2008
dc.identifier.issn00333158
dc.identifier.urihttp://hdl.handle.net/10234/12616
dc.description.abstractRationale: Nucleus accumbens dopamine (DA) participates in the modulation of instrumental behavior, including aspects of behavioral activation and effort-related choice behavior. Rats with impaired accumbens DA transmission reallocate their behavior away from food-reinforced activities that have high response requirements, and instead select less-effortful types of food-seeking behavior. Although accumbens DA is considered a critical component of the brain circuitry regulating effort-related processes, emerging evidence also implicates adenosine A2A receptors. Objective: The present work was undertaken to test the hypothesis that accumbens A2A receptor stimulation would produce effects similar to those produced by DA depletion or antagonism. Methods: Three experiments assessed the effects of the adenosine A2A agonist CGS 21680 on performance of a concurrent choice task (lever pressing for preferred food vs. intake of less preferred chow) that is known to be sensitive to DA antagonists and accumbens DA depletions. Results: Systemic injections of CGS 21680 reduced lever pressing but did not increase feeding. In contrast, bilateral infusions of the adenosine A2A receptor agonist CGS 21680 (6.0- 24.0 ng) into the nucleus accumbens decreased lever pressing for the preferred food, but substantially increased consumption of the less preferred chow. Injections of CGS 21680 into a control site dorsal to the accumbens were ineffective. Conclusions: Taken together, these results are consistent with the hypothesis that local stimulation of adenosine A2A receptors in nucleus accumbens produces behavioral effects similar to those induced by accumbens DA depletions. Accumbens adenosine A2A receptors appear to be a component of the brain circuitry regulating effort-related choice behavioren
dc.format.extent11 p.
dc.language.isoengen
dc.publisherSpringer Verlagen
dc.relation.isPartOfSeriesPsychopharmacology; vol. 199 núm. 4
dc.rights.urihttp://rightsstatements.org/vocab/CNE/1.0/*
dc.subjectDecision makingen
dc.subjectMotivationen
dc.subjectActivationen
dc.subjectAnergiaen
dc.subjectDepressionen
dc.subjectNucleus accumbensen
dc.subjectDopamineen
dc.subject.otherPsicobiologia
dc.subject.otherPsicofarmacologia
dc.subject.otherDopamina
dc.titleIntra-accumbens injections of the adenosine A(2A) agonist CGS 21680 affect effort-related choice behavior in ratsen
dc.typeinfo:eu-repo/semantics/articleen
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess
dc.type.versioninfo:eu-repo/semantics/acceptedVersionca_CA


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