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Qualitative screening of 116 veterinary drugs in feed by liquid chromatography-high resolution mass spectrometry. Potential application to quantitative analysis
dc.contributor.author | Boix Sales, Clara | |
dc.contributor.author | Ibáñez, Maria | |
dc.contributor.author | Sancho, Juan V | |
dc.contributor.author | León, Nuria | |
dc.contributor.author | Yusà, Vicent | |
dc.contributor.author | Hernandez, Felix | |
dc.date.accessioned | 2015-07-01T14:48:51Z | |
dc.date.available | 2015-07-01T14:48:51Z | |
dc.date.issued | 2014 | |
dc.identifier.issn | 0308-8146 | |
dc.identifier.uri | http://hdl.handle.net/10234/125766 | |
dc.description.abstract | Veterinarian and human pharmaceuticals may be intentionally added to animal feed to enhance animal production. Monitoring these substances is necessary for protecting the consumers. In this work, a screening method covering 116 human and veterinary drugs has been developed and validated in five types of animal feed at 0.02 and 0.2 mg kg−1. After a simple extraction and dilution, the samples were analysed by ultra-high performance liquid chromatography coupled to quadrupole time-of-flight mass spectrometry (UHPLC-QTOF MS). Nearly all compounds tested were detected at 0.02 mg kg−1, based on the presence of the accurate-mass (de)protonated molecule. However, the identification using a second accurate-mass ion was more problematic at this level. Finally, the procedure was applied to 22 feed samples, where trimethoprim, robenidine, or α- and β-nandrolone were detected and identified. The potential applicability of the method to quantitative analysis of the compounds detected in the samples was also evaluated. | ca_CA |
dc.format.extent | 7 p. | ca_CA |
dc.format.mimetype | application/pdf | ca_CA |
dc.language.iso | eng | ca_CA |
dc.publisher | Elsevier | ca_CA |
dc.relation.isPartOf | Food Chemistry, 2014, nº 160 | ca_CA |
dc.rights.uri | http://rightsstatements.org/vocab/CNE/1.0/ | * |
dc.subject | veterinary drugs | ca_CA |
dc.subject | animal feed | ca_CA |
dc.subject | liquid chromatography | ca_CA |
dc.subject | time-of-flight mass spectrometry | ca_CA |
dc.subject | screening | ca_CA |
dc.subject | qualitative validation | ca_CA |
dc.title | Qualitative screening of 116 veterinary drugs in feed by liquid chromatography-high resolution mass spectrometry. Potential application to quantitative analysis | ca_CA |
dc.type | info:eu-repo/semantics/article | ca_CA |
dc.identifier.doi | http://dx.doi.org/10.1016/j.foodchem.2014.03.086 | |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | ca_CA |
dc.relation.publisherVersion | http://www.sciencedirect.com/science/article/pii/S0308814614004774 | ca_CA |
dc.type.version | info:eu-repo/semantics/acceptedVersion |
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