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dc.contributor.authorPeña Llopis, Samuel
dc.contributor.authorSerrano Gallego, Roque
dc.contributor.authorPitarch Arquimbau, María Elena
dc.contributor.authorBeltrán Iturat, Eduardo
dc.contributor.authorIbáñez Martínez, María
dc.contributor.authorHernández Hernández, Félix
dc.contributor.authorPeña, Juan B.
dc.date.accessioned2015-07-01T09:41:58Z
dc.date.available2015-07-01T09:41:58Z
dc.date.issued2014-09
dc.identifier.issn0166-445X
dc.identifier.urihttp://hdl.handle.net/10234/125626
dc.description.abstractWater pollution represents a threat of increasing importance to human health. Bivalve mollusks are filter-feeding organisms that can accumulate chemical and microbiological contaminants in their tissues from very low concentrations in the water or sediments. Consumption of contaminated shellfish is one of the main causes of seafood poisoning. Thus, marine bivalves are normally depurated in sterilized seawater for 48 h to allow the removal of bacteria. However, this depuration time might be insufficient to eliminate chemical contaminants from their tissues. We have developed a novel technology that accelerates up to fourfold the excretion rate of xenobiotics in bivalves by treatment with the antioxidant and glutathione (GSH) pro-drug N-acetylcysteine (NAC) during the depuration period. NAC improved dose-dependently the detoxification of the organophosphate (OP) pesticide fenitrothion in the mussel Mytilus galloprovincialis, diminishing its levels up to nearly a hundred fold compared to conventional depuration, by enhancing the glutathione S-transferase (GST) activity and inducing the GSH anabolism (GSH synthesis and reduction by glutathione reductase). Notably, this induction in GSH anabolism and GST activity was also observed in uncontaminated bivalves treated with NAC. As the GSH pathway is involved in the detoxification of many pollutants and biotoxins from harmful algal blooms, we validated this proof of principle in king scallops (Pecten maximus) that naturally accumulated the amnesic shellfish poisoning (ASP) toxin domoic acid. We illustrate here a method that enhances the elimination of organic contaminants in shellfish, opening new avenues of depuration of marine organisms.ca_CA
dc.format.extent10 p.ca_CA
dc.format.mimetypeapplication/pdfca_CA
dc.language.isoengca_CA
dc.publisherElsevierca_CA
dc.relation.isPartOfAquatic Toxicology Vol. 154, 2014ca_CA
dc.rightsCopyright © 2015 Elsevier B.V.ca_CA
dc.subjectN-Acetyl-L-cysteineca_CA
dc.subjectBivalve molluscsca_CA
dc.subjectToxicokineticsca_CA
dc.subjectOrganophosphorus pesticidesca_CA
dc.subjectRed tidesca_CA
dc.subjectOxidative stressca_CA
dc.titleN-Acetylcysteine boosts xenobiotic detoxification in shellfishca_CA
dc.typeinfo:eu-repo/semantics/articleca_CA
dc.identifier.doihttp://dx.doi.org/10.1016/j.aquatox.2014.05.006
dc.rights.accessRightsinfo:eu-repo/semantics/restrictedAccessca_CA
dc.relation.publisherVersionhttp://www.sciencedirect.com/science/article/pii/S0166445X14001659#ca_CA


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