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dc.contributor.authorAgrawal, Nitasha
dc.contributor.authorMarco Peiró, Sergio
dc.contributor.authorEsteve-Romero, Josep
dc.contributor.authorDurgbanshi, Abhilasha
dc.contributor.authorBose, Devasish
dc.contributor.authorVives-Peris, Vicente
dc.contributor.authorCarda-Broch, Samuel
dc.date.accessioned2015-06-19T11:38:55Z
dc.date.available2015-06-19T11:38:55Z
dc.date.issued2015-06-19
dc.identifier.issn0021-9665
dc.identifier.urihttp://hdl.handle.net/10234/124425
dc.description.abstractParoxetine is a potent selective serotonin reuptake inhibitor used for the treatment of depression and related mood disorders. A micellar liquid chromatographic method was developed for the determination of paroxetine in serum and urine. Detection of paroxetine was carried out using a C18 column and a mobile phase of 0.15 M sodium dodecyl sulfate, 6% 1-pentanol at pH 3 (buffer salt 0.01 M NaH2PO4) running under isocratic mode at 1.0 mL/min and electrochemical detection at 0.8 V. The analyte was eluted without interferences in <15 min. The proposed methodology was validated under the guidelines of the International Conference on Harmonization of Technical Requirements for Registration of Pharmaceuticals for Human Use in matrix in terms of specificity, linearity (r2 > 0.9999; 0.5–5 μg/mL range), accuracy (88–97.5%, recovery), repeatability (RSD < 0.54%), intermediate precision (RSD < 0.54%), limit of detection and quantification (0.001 and 0.005 μg/mL, respectively) and robustness (RSD < 3.63%). Developed method was successfully applied to real blood and urine samples as well as in spiked serum and urine samples. The developed method was specific, rapid, precise, reliable, accurate, inexpensive and then suitable for routine analysis of paroxetine in monitorized samples.ca_CA
dc.format.extent7 p.ca_CA
dc.language.isoengca_CA
dc.relation.isPartOfJournal of chromatographic science, 2014, bmt200ca_CA
dc.rightsCopyright © 2014 Oxford University Pressca_CA
dc.rights.urihttp://rightsstatements.org/vocab/InC/1.0/*
dc.subjectParoxetineca_CA
dc.titleDetermination of paroxetine in blood and urine using micellar liquid chromatography with electrochemical detectionca_CA
dc.typeinfo:eu-repo/semantics/articleca_CA
dc.identifier.doi10.1093/chromsci/bmt200
dc.rights.accessRightsinfo:eu-repo/semantics/restrictedAccessca_CA
dc.relation.publisherVersionhttp://chromsci.oxfordjournals.org/content/early/2014/01/20/chromsci.bmt200.full#content-blockca_CA
dc.editionCopyright © 2014 Oxford University Pressca_CA
dc.type.versioninfo:eu-repo/semantics/publishedVersionca_CA


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