Mostrar el registro sencillo del ítem

dc.contributor.authorPeris Vicente, Juan
dc.contributor.authorCarda-Broch, Samuel
dc.contributor.authorEsteve-Romero, Josep
dc.date.accessioned2015-06-02T06:47:53Z
dc.date.available2015-06-02T06:47:53Z
dc.date.issued2014
dc.identifier.citationPERIS VICENTE, J.; CARDA BROCH, S.; ESTEVE ROMERO, J. Quantification of Tamoxifen in Pharmaceutical Formulations Using Micellar Liquid Chromatography. Analytical Sciences, v. 30, n. 9 (2014), p. 925-930ca_CA
dc.identifier.urihttp://hdl.handle.net/10234/122403
dc.description.abstractThis paper describes a micellar liquid chromatographic method used to analyze tamoxifen (TAMO) in pharmaceutical formulations, while focusing in its interesting features. Solid samples were solved in a micellar solution, irradiated at 254 nm, filtered and injected. Extraction steps were avoided and thus expediting the procedure. Tamoxifen was resolved in <5 min, using a mobile phase containing 0.15 M sodium dodecyl sulfate–7% pentanol at pH 3, running at 1.5 mL/min under an isocratic mode at 40°C through a C18 column. Detection was achieved by fluorescence by excitation at 260 nm and emission at 380 nm. The validation was performed following the requirements of the International Conference on Harmonization (ICH) Tripartite Guidelines in terms of: specificity, sensitivity, calibration range (0.2 – 20 mg/L), accuracy (98.8 – 101.7%), precision (<1.5%) and robustness (<6.2%). The method was applied to quantify TAMO in TAMO citrate tablets supplied in Spain, and was found appropriate for the quality control of TAMO formulationsca_CA
dc.format.extent6 p.ca_CA
dc.format.mimetypeapplication/pdfca_CA
dc.language.isoengca_CA
dc.publisherJapan Society for Analytical Chemistryca_CA
dc.relation.isPartOfAnalytical Sciences, v. 30, n. 9 (2014)ca_CA
dc.subjectCancerca_CA
dc.subjectFormulationca_CA
dc.subjectMicellarca_CA
dc.subjectTamoxifenca_CA
dc.subjectValidationca_CA
dc.titleQuantification of Tamoxifen in Pharmaceutical Formulations Using Micellar Liquid Chromatographyca_CA
dc.typeinfo:eu-repo/semantics/articleca_CA
dc.identifier.doihttp://dx.doi.org/10.2116/analsci.30.925
dc.rights.accessRightsinfo:eu-repo/semantics/openAccessca_CA
dc.relation.publisherVersionhttp://www.jsac.or.jp/analsci/toc.php/30/9/ca_CA


Ficheros en el ítem

Thumbnail

Este ítem aparece en la(s) siguiente(s) colección(ones)

Mostrar el registro sencillo del ítem