Quantification of Tamoxifen in Pharmaceutical Formulations Using Micellar Liquid Chromatography
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Otros documentos de la autoría: Vives-Peris, Vicente; Carda-Broch, Samuel; Esteve-Romero, Josep
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Mostrar el registro completo del ítemcomunitat-uji-handle:10234/9
comunitat-uji-handle2:10234/7013
comunitat-uji-handle3:10234/8638
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Título
Quantification of Tamoxifen in Pharmaceutical Formulations Using Micellar Liquid ChromatographyFecha de publicación
2014Editor
Japan Society for Analytical ChemistryCita bibliográfica
PERIS VICENTE, J.; CARDA BROCH, S.; ESTEVE ROMERO, J. Quantification of Tamoxifen in Pharmaceutical Formulations Using Micellar Liquid Chromatography. Analytical Sciences, v. 30, n. 9 (2014), p. 925-930Tipo de documento
info:eu-repo/semantics/articleVersión de la editorial
http://www.jsac.or.jp/analsci/toc.php/30/9/Versión
info:eu-repo/semantics/publishedVersionPalabras clave / Materias
Resumen
This paper describes a micellar liquid chromatographic method used to analyze tamoxifen (TAMO) in pharmaceutical formulations, while focusing in its interesting features. Solid samples were solved in a micellar solution, ... [+]
This paper describes a micellar liquid chromatographic method used to analyze tamoxifen (TAMO) in pharmaceutical formulations, while focusing in its interesting features. Solid samples were solved in a micellar solution, irradiated at 254 nm, filtered and injected. Extraction steps were avoided and thus expediting the procedure. Tamoxifen was resolved in <5 min, using a mobile phase containing 0.15 M sodium dodecyl sulfate–7% pentanol at pH 3, running at 1.5 mL/min under an isocratic mode at 40°C through a C18 column. Detection was achieved by fluorescence by excitation at 260 nm and emission at 380 nm. The validation was performed following the requirements of the International Conference on Harmonization (ICH) Tripartite Guidelines in terms of: specificity, sensitivity, calibration range (0.2 – 20 mg/L), accuracy (98.8 – 101.7%), precision (<1.5%) and robustness (<6.2%). The method was applied to quantify TAMO in TAMO citrate tablets supplied in Spain, and was found appropriate for the quality control of TAMO formulations [-]
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Analytical Sciences, v. 30, n. 9 (2014)Derechos de acceso
http://rightsstatements.org/vocab/CNE/1.0/
info:eu-repo/semantics/openAccess
info:eu-repo/semantics/openAccess
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