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dc.contributor.authorCeci, Roberta
dc.contributor.authorDuranti, Guglielmo
dc.contributor.authorDimauro, Ivan
dc.contributor.authorQuaranta, Federico
dc.contributor.authorPittaluga, Monica
dc.contributor.authorSabatini, Stefania
dc.contributor.authorCaserotti, Paolo
dc.contributor.authorParisi, Paolo
dc.contributor.authorParisi, Attilio
dc.contributor.authorCaporossi, Daniela
dc.contributor.authorBeltran Valls, Maria Reyes
dc.date.accessioned2015-05-18T13:09:55Z
dc.date.available2015-05-18T13:09:55Z
dc.date.issued2014
dc.identifier.citationCECI, Roberta, et al. Oxidative stress responses to a graded maximal exercise test in older adults following explosive-type resistance training. Redox biology, 2014, vol. 2, p. 65-72ca_CA
dc.identifier.issn2213-2317
dc.identifier.urihttp://hdl.handle.net/10234/121144
dc.description.abstractWe recently demonstrated that low frequency, moderate intensity, explosive-type resistance training (EMRT) is highly beneficial in elderly subjects towards muscle strength and power, with a systemic adaptive response of anti-oxidant and stress-induced markers. In the present study, we aimed to evaluate the impact of EMRT on oxidative stress biomarkers induced in old people (70–75 years) by a single bout of acute, intense exercise. Sixteen subjects randomly assigned to either a control, not exercising group (n=8) or a trained group performing EMRT protocol for 12-weeks (n=8), were submitted to a graded maximal exercise stress test (GXT) at baseline and after the 12-weeks of EMRT protocol, with blood samples collected before, immediately after, 1 and 24 h post-GXT test. Blood glutathione (GSH, GSSG, GSH/GSSG), plasma malonaldehyde (MDA), protein carbonyls and creatine kinase (CK) levels, as well as PBMCs cellular damage (Comet assay, apoptosis) and stress–protein response (Hsp70 and Hsp27 expression) were evaluated. The use of multiple biomarkers allowed us to confirm that EMRT per se neither affected redox homeostasis nor induced any cellular and oxidative damage. Following the GXT, the EMRT group displayed a higher GSH/GSSG ratio and a less pronounced increase in MDA, protein carbonyls and CK levels compared to control group. Moreover, we found that Hsp70 and Hsp27 proteins were induced after GXT only in EMRT group, while any significant modification within 24 h was detected in untrained group. Apoptosis rates and DNA damage did not show any significant variation in relation to EMRT and/or GXT. In conclusion, the adherence to an EMRT protocol is able to induce a cellular adaptation allowing healthy elderly trained subjects to cope with the oxidative stress induced by an acute exercise more effectively than the aged-matched sedentary subjects.ca_CA
dc.format.extent8 p.ca_CA
dc.format.mimetypeapplication/pdfca_CA
dc.language.isoengca_CA
dc.publisherElsevierca_CA
dc.relation.isPartOfRedox biology (2014) vol. 2, pp. 65-72ca_CA
dc.rights© 2013 The Authorsca_CA
dc.rightsAttribution-NonCommercial-ShareAlike 4.0 Spain*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/*
dc.subjectexplosive-type moderate intensity resistance training (EMRT)ca_CA
dc.subjectgraded maximal exercise test (GXT)ca_CA
dc.subjectoxidative stressca_CA
dc.subjectHSPsca_CA
dc.subjectapoptosisca_CA
dc.subjectelderlyca_CA
dc.titleOxidative stress responses ti a graded maximal exercise test in older adults following explosive-type resistance trainingca_CA
dc.typeinfo:eu-repo/semantics/articleca_CA
dc.identifier.doihttp://dx.doi.org/10.1016/j.redox.2013.12.004
dc.rights.accessRightsinfo:eu-repo/semantics/openAccessca_CA
dc.relation.publisherVersionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC4297938/ca_CA


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