Listar por tema "viruses"
Mostrando ítems 1-3 de 3
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Molecular Insights into the Substrate-Assisted Mechanism of Viral DNA 3′-End Processing in Intasome of Prototype Foamy Virus Integrase from Molecular Dynamic and QM/MM Studies
American Chemical Society (2019-05)Integrases participate in two important steps for virus replication such as 3′-end processing of viral DNA (vDNA) and nuclear entry of host DNA (hDNA). In this work, insight into the structural changes in intasome of ... -
Revealing the molecular mechanisms of proteolysis of SARS-CoV-2 Mpro by QM/MM computational methods
Royal Society of Chemistry (2020-06-25)SARS-CoV-2 Mpro is one of the enzymes essential for the replication process of the virus responsible for the COVID-19 pandemic. This work is focused on exploring its proteolysis reaction by means of QM/MM methods. The ... -
Viroporins: A new target for fighting viral infections
SBE - Sociedad de Biofísica de España (2017)Over the last years an increasing number of viruses have jumped into the mass media and several names or acronyms (Ebola, zika, SARS, MERS,…) have become familiar to the general public because of the high mortality rates ...