• openAccess   1-Methyltryptophan Treatment Increases Defense-Related Proteins in the Apoplast of Tomato Plants 

      Llorens, Eugenio; Scalschi, Loredana; González-Hernández, Ana I.; Camañes, Gemma; García Agustín, Pilar; Vicedo, Begonya American Chemical Society (2020-09-29)
      The activation of induced resistance in plants may enhance the production of defensive proteins to avoid the invasion of pathogens. In this way, the composition of the apoplastic fluid could represent an important layer ...
    • openAccess   A possible use of melatonin in the dental field: Protein adsorption andinvitrocell response on coated titanium 

      Cerqueira, Andreia; Romero-Gavilán, Francisco J; Araújo-Gomes, Nuno; García-Arnáez, Iñaki; Martinez Ramos, Cristina; Ozturan, Seda; Azkargorta, Mikel; Elortza, Felix; GURRUCHAGA, MARILO; Suay, Julio; Goñi, Isabel Elsevier (2020)
      Melatonin (MLT) is widely known for regulating the circadian cycles and has been studied for its role in boneregeneration and inflammation. Its application as a coating for dental implants can condition the local ...
    • openAccess   Bioactive potential of silica coatings and its effect on the adhesion of proteins to titanium implants 

      Romero-Gavilán, Francisco J; Gomes, Nuno; Sánchez-Pérez, Ana María; García-Arnáez, Iñaki; Elortza, Felix; Azkargorta, Mikel; Martín de Llano, J.J.; Carda, C.; Gurruchaga, Marilo; Suay, Julio; Goñi, Isabel Elsevier (2018-02-01)
      There is an ever-increasing need to develop dental implants with ideal characteristics to achieve specific and desired biological response in the scope of improve the healing process post-implantation. Following that ...
    • openAccess   Characterization of magnesium doped sol-gel biomaterial for bone tissue regeneration: The effect of Mg ion in protein adsorption 

      Cerqueira, Andreia; Romero-Gavilán, Francisco J; García-Arnáez, Iñaki; Martinez Ramos, Cristina; Ozturan, Seda; Izquierdo Escrig, Raul; Azkargorta, Mikel; Elortza, Felix; GURRUCHAGA, MARILO; Suay, Julio; Goñi, Isabel Elsevier (2021-06-01)
      Magnesium is the fourth most abundant element in the human body with a wide battery of functions in the maintenance of normal cell homeostasis. In the bone, this element incorporates in the hydroxyapatite structure and it ...
    • openAccess   Characterization of serum proteins attached to distinct sol–gel hybrid surfaces 

      Gomes, Nuno; Romero-Gavilán, Francisco J; Sánchez-Pérez, Ana María; GURRUCHAGA, MARILO; Azkargorta, Mikel; Elortza, Felix; Ibáñez, Maria; Iloro, Ibon; Suay, Julio; Goñi, Isabel Wiley (2017-07)
      The success of a dental implant depends on its osseointegration, an important feature of the implant biocompatibility. In this study, two distinct sol–gel hybrid coating formulations [50% methyltrimethoxysilane: 50% ...
    • openAccess   Complement proteins regulating macrophage polarisation on biomaterials 

      Gomes, Nuno; Romero-Gavilán, Francisco J; Zhang, Yiyue; Martinez Ramos, Cristina; Elortza, Felix; Azkargorta, Mikel; Martín de Llano, J. J.; GURRUCHAGA, MARILO; Goñi, Isabel; van den Beucken, J.J.J.P.; Suay, Julio Elsevier (2019-09-01)
      One of the events occurring when a biomaterial is implanted in an host is the protein deposition onto its surface, which might regulate cell responses. When a biomaterial displays a compromised biocompatibility, distinct ...
    • openAccess   Complex effects of Mg-biomaterials on the osteoblast cell machinery: A proteomic study 

      Cerqueira, Andreia; García-Arnáez, Iñaki; Romero-Gavilán, Francisco J; Azkargorta, Mikel; Elortza, Felix; Martín de Llanos, José Javier; Carda, Carmen; GURRUCHAGA, MARILO; Goñi, Isabel; Suay, Julio Elsevier (2022)
      The cell–biomaterial interface is highly complex; thousands of molecules and many processes participate in its formation. Growing demand for improved biomaterials has highlighted the need to understand the structure and ...
    • openAccess   Correlation between biological responses in vitro and in vivo to Ca-doped sol-gel coatings assessed using proteomic analysis 

      García-Arnáez, Iñaki; Romero-Gavilán, Francisco J; Cerqueira, Andreia; Elortza, Felix; Azkargorta, Mikel; Muñoz Guzón, Fernando; Mata Roig, Manuel; MARTIN DE LLANO, JOSE JAVIER; Suay, Julio; GURRUCHAGA, MARILO; Goñi, Isabel Elsevier (2022-10-21)
      Poor correlation between the results of in vitro testing and the subsequent in vivo experiments hinders the design of biomaterials. Thus, new characterisation methods are needed. This study used proteomic and histological ...
    • openAccess   Development and characterisation of strontium-doped sol-gel coatings to optimise the initial bone regeneration processes 

      García-Arnáez, Iñaki; Cerqueira, Andreia; Romero-Gavilán, Francisco J; Elortza, Felix; Azkargorta, Mikel; Iloro, Ibon; Suay, Julio; Goñi, Isabel; GURRUCHAGA, MARILO Elsevier (2022)
      Strontium plays an important role in bone regeneration; it promotes the differentiation and maturation of osteoblasts and inhibits the activity of osteoclasts. Our principal objective in this study was to formulate new ...
    • openAccess   From Classical to Modern Computational Approaches to Identify Key Genetic Regulatory Components in Plant Biology 

      Acién, Juan Manuel; Cañizares Ramos, Eva; Candela, Héctor; Gonzalez-Guzman, Miguel; Arbona, Vicent MDPI (2023-01-28)
      The selection of plant genotypes with improved productivity and tolerance to environmental constraints has always been a major concern in plant breeding. Classical approaches based on the generation of variability and ...
    • openAccess   Protein adsorption/desorption dynamics on Ca‑enriched titanium surfaces: biological implications 

      Romero-Gavilán, Francisco J; Cerqueira, Andreia; Anitua, Eduardo; Tejero, Ricardo; García-Arnáez, Iñaki; Martinez Ramos, Cristina; Ozturan, Seda; Izquierdo Escrig, Raul; Azkargorta, Mikel; Elortza, Felix; GURRUCHAGA, MARILO; Goñi, Isabel; Suay, Julio Springer (2021-08-27)
      Calcium ions are used in the development of biomaterials for the promotion of coagulation, bone regeneration, and implant osseointegration. Upon implantation, the time-dependent release of calcium ions from titanium implant ...
    • openAccess   Proteome analysis of human serum proteins adsorbed onto different titanium surfaces used in dental implants 

      Romero-Gavilán, Francisco J; Gomes, N. C.; Ródenas, Joaquin; Sánchez, Ana; Azkargorta, Mikel; Iloro, Ibon; Elortza, Felix; García-Arnáez, Iñaki; GURRUCHAGA, MARILO; Goñi, Isabel; Suay, Julio Taylor & Francis (2017)
      Titanium dental implants are commonly used due to their biocompatibility and biochemical properties; blasted acid-etched Ti is used more frequently than smooth Ti surfaces. In this study, physico-chemical characterisation ...
    • openAccess   Proteomic Analysis of Mesenchymal Stem Cells and Monocyte Co-Cultures Exposed to a Bioactive Silica-Based Sol–Gel Coating 

      Cerqueira, Andreia; Romero-Gavilán, Francisco J; Helmholz, Heike; Azkargorta, Mikel; Elortza, Félix; Gurruchaga, Mariló; Goñi, Isabel; Willumeit-Römer, Regine; Suay, Julio American Chemical Society (2023)
      New methodologies capable of extensively analyzing the cell-material interactions are necessary to improve current in vitro characterization methods, and proteomics is a viable alternative. Also, many studies are focused ...
    • openAccess   Proteomics as a tool to study the osteoimmunomodulatory role of metallic ions in a sol–gel coating 

      García-Arnáez, Iñaki; Romero-Gavilán, Francisco J; Cerqueira, Andreia; Azkargorta, Mikel; Elortza, Félix; Suay, Julio; Goñi, Isabel; Gurruchaga, Mariló Royal Society of Chemistry (2023)
      The success of bone implants depends on the osteoimmunomodulatory (OIM) activity of the biomaterials in the interactions with the periimplantary tissues. Many in vitro tests have been conducted to evaluate the osteoimmunology ...
    • closedAccess   The 'prime-ome': towards a holistic approach to priming 

      Balmer, Andrea; Pastor, Victoria; Gamir, Jordi; Flors, Victor; Mauch-Mani, Brigitte Elsevier (2015-07)
      Plants can be primed to respond faster and more strongly to stress and multiple pathways, specific for the encountered challenge, are involved in priming. This adaptability of priming makes it difficult to pinpoint an exact ...
    • openAccess   The Cluster Transfer Function of AtNEET Supports the Ferredoxin–Thioredoxin Network of Plant Cells 

      I Zandalinas, Sara; Song, Luhua; Nechushtai, Rachel; Mendoza-Cozatl, David G.; Mittler, Ron MDPI (2022-08)
      NEET proteins are conserved 2Fe-2S proteins that regulate the levels of iron and reactive oxygen species in plant and mammalian cells. Previous studies of seedlings with constitutive expression of AtNEET, or its dominant-negative ...
    • openAccess   The effect of calcium–magnesium mixtures in sol–gel coatings on bone tissue regeneration 

      Cerqueira, Andreia; García-Arnáez, Iñaki; Muriach, Maria; Azkargorta, Mikel; Elortza, Felix; Izquierdo, Raúl; Romero-Gavilán, Francisco J; GURRUCHAGA, MARILO; Suay, Julio; Goñi, Isabel Royal Society of Chemistry (2022)
      Calcium and magnesium are two elements essential for bone structure and metabolism. However, their synergistic or competitive effects on bone regeneration are often overlooked during biomaterial development. We examined ...
    • openAccess   The effect of strontium incorporation into sol-gel biomaterials on their protein adsorption and cell interactions 

      Romero-Gavilán, Francisco J; Gomes, Nuno; García-Arnáez, Iñaki; Martinez Ramos, Cristina; Elortza, Felix; Azkargorta, Mikel; Iloro, Ibon; GURRUCHAGA, MARILO; Suay, Julio; Goñi, Isabel Elsevier (2019-02-01)
      It is known strontium can both inhibit the osteoclast formation and stimulate the osteoblast maturation, so biomaterials containing this element can favour bone structure stabilisation. The addition of Sr to biomaterials ...
    • openAccess   The effects of multifactorial stress combination on rice and maize 

      Sinha, Ranjita; Peláez Vico, María Ángeles; Shostak, Ben; Nguyen, Thao Thi; Soto Pascual, Lidia; Ogden, Andrew; Zhen, Lyu; I Zandalinas, Sara; Joshi, Trupti; Fritschi, Felix; Mittler, Ron Oxford University Press (2023-10-17)
      The complexity of environmental factors affecting crops in the field is gradually increasing due to climate change-associated weather events, such as droughts or floods combined with heat waves, coupled with the accumulation ...