• openAccess   Aryl azoles based scaffolds for disrupting tumor microenvironment 

      Pla López, Alberto; Martinez-Colomina, Paula; Cañada-García, Laura; Fuertes-Monge, Laura; Orellana-Palacios, Jose C.; Valderrama-Martínez, Alejandro; Pérez Sosa, Marikena; Carda, Miguel; Falomir, Eva Elsevier (2023-11-15)
      Thirty-nine aryl azoles, thirteen triazoles and twenty-seven tetrazoles, have been synthetized and biologically evaluated to determine their activity as tumor microenvironment disruptors. Antiproliferative studies have ...
    • openAccess   Aryl urea based scaffolds for multitarget drug discovery in anticancer immunotherapies 

      Martín Beltrán, Celia; Gil-Edo, Raquel; Hernández Ribelles, Germán; Agut, Raúl; Marí Mezquita, Pilar; Carda, Miguel; Falomir, Eva MDPI (2021-04-06)
      Twenty-one styryl and phenethyl aryl ureas have been synthetized and biologically evaluated as multitarget inhibitors of Vascular endothelial growth factor receptor-2 VEGFR-2 and programmed death-ligand-1 (PD-L1) proteins ...
    • openAccess   Exploring BenzylethoxyAryl Urea Scaffolds for Multitarget Immunomodulation Therapies 

      Gil-Edo, Raquel; Hernández Ribelles, Germán; Royo, Santiago; Thawait, Natasha; Serrels, Alan; Carda, Miguel; Falomir, Eva MDPI (2023-05-11)
      Thirteen benzylethoxyaryl ureas have been synthesized and biologically evaluated as multitarget inhibitors of VEGFR-2 and PD-L1 proteins to overcome resistance phenomena offered by cancer. The antiproliferative activity ...
    • openAccess   Novel multitarget inhibitors with antiangiogenic and immunomodulator properties 

      Conesa Milián, Laura; Falomir, Eva; Murga, Juan; Carda, Miguel; Marco, J. Alberto Elsevier (2019-03-08)
      By means of docking studies, seventeen compounds T.1-T17 have been designed and evaluated as multitarget inhibitors of VEGFR-2 and PD-L1 proteins in order to overcome resistance phenomena offered by cancer. All these ...
    • closedAccess   Synthesis and biological evaluation as antiangiogenic agents of ureas derived from 3′-aminocombretastatin A-4 

      Conesa Milián, Laura; Falomir, Eva; Murga, Juan; Carda, Miguel; Marco, J. Alberto Elsevier (2019-01-15)
      Twenty-six compounds derived from 3′-aminocombretastatin A-4 (AmCA-4) containing a urea fragment mimicking the structure of Sorafenib, have been synthesized and evaluated as antiangiogenic compounds. Antiproliferative ...
    • openAccess   Synthesis and Biological Evaluation of Small Molecules as Potential Anticancer Multitarget Agents 

      Pla López, Alberto; Castillo, Raquel; Cejudo Marín, Rocío; García Pedrero, Olaya; Bakir Laso, Mariam; Falomir, Eva; Miguel Carda MDPI (2022-06-24)
      Twenty-six triazole-based derivatives were designed for targeting both PD-L1 (programmed death receptor ligand 1) and VEGFR-2 (vascular endothelial growth factor receptor 2). These compounds were synthetized and biologically ...
    • openAccess   Synthesis of combretastatin analogues with antineoplastic properties 

      Conesa Milián, Laura Universitat Jaume I (2019-06-25)
      This doctoral thesis belongs to the field of medicinal and pharmacological chemistry. Its aim is the synthesis, characterization and biological evaluation of three families of aminocombretastatin derivatives, compound with ...
    • openAccess   Tetrazole derivatives as potent immunomodulatory agents in tumor microenvironment 

      Pla López, Alberto; Carda, Miguel; Falomir, Eva Elsevier (2023-11-01)
      Twenty-seven compounds bearing a tetrazole ring as a central unit have been designed, synthetized and biologically evaluated. Studies have been performed in order to compare the effect of tetrazole derivatives bearing amine ...
    • openAccess   Unveiling the Potential of BenzylethyleneAryl–Urea Scaffolds for the Design of New Onco Immunomodulating Agents 

      Gil-Edo, Raquel; Royo, Santiago; Carda, Miguel; Falomir, Eva MDPI (2023)
      This work focuses on the development of thirteen benzylethylenearyl ureas and one carbamate. After the synthesis and purification of the compounds, we studied their antiproliferative action on cell lines, such as HEK-293, ...