Listar por tema "PD-L1"
Mostrando ítems 1-11 de 11
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Aryl azoles based scaffolds for disrupting tumor microenvironment
Elsevier (2023-11-15)Thirty-nine aryl azoles, thirteen triazoles and twenty-seven tetrazoles, have been synthetized and biologically evaluated to determine their activity as tumor microenvironment disruptors. Antiproliferative studies have ... -
Aryl urea based scaffolds for multitarget drug discovery in anticancer immunotherapies
MDPI (2021-04-06)Twenty-one styryl and phenethyl aryl ureas have been synthetized and biologically evaluated as multitarget inhibitors of Vascular endothelial growth factor receptor-2 VEGFR-2 and programmed death-ligand-1 (PD-L1) proteins ... -
Exploring BenzylethoxyAryl Urea Scaffolds for Multitarget Immunomodulation Therapies
MDPI (2023-05-11)Thirteen benzylethoxyaryl ureas have been synthesized and biologically evaluated as multitarget inhibitors of VEGFR-2 and PD-L1 proteins to overcome resistance phenomena offered by cancer. The antiproliferative activity ... -
Novel multitarget inhibitors with antiangiogenic and immunomodulator properties
Elsevier (2019-03-08)By means of docking studies, seventeen compounds T.1-T17 have been designed and evaluated as multitarget inhibitors of VEGFR-2 and PD-L1 proteins in order to overcome resistance phenomena offered by cancer. All these ... -
Síntesis y evaluación biológica de compuestos de actividad dual anti-c-Myc y anti-PD-L1
Universitat Jaume I (2016)El objetivo de este Trabajo de Fin de Máster es la búsqueda de compuestos con actividad dual en c-Myc y PD-L1. En los últimos cinco años, el grupo de investigación de Síntesis Orgánica de la Universidad Jaume I, donde ... -
Styryl carbamate backbones for the discovery of TME-disrupting agents
Elsevier (2024)Twenty-one styryl carbamates have been designed, synthetized and characterized by their physical properties. Afterwards, their potential activity as tumor microenvironment disruptors has been evaluated. First, antiproliferative ... -
Synthesis and Biological Evaluation of Potential Oncoimmunomodulator Agents
MDPI (2023-01-30)Fourteen triazole-scaffold derivatives were synthetized and biologically evaluated as potential oncoimmunomodultator agents by targeting both PD-L1 and c-Myc. First, the antiproliferative activity of these molecules on the ... -
Synthesis and Biological Evaluation of Small Molecules as Potential Anticancer Multitarget Agents
MDPI (2022-06-24)Twenty-six triazole-based derivatives were designed for targeting both PD-L1 (programmed death receptor ligand 1) and VEGFR-2 (vascular endothelial growth factor receptor 2). These compounds were synthetized and biologically ... -
Synthesis of combretastatin analogues with antineoplastic properties
Universitat Jaume I (2019-06-25)This doctoral thesis belongs to the field of medicinal and pharmacological chemistry. Its aim is the synthesis, characterization and biological evaluation of three families of aminocombretastatin derivatives, compound with ... -
Tetrazole derivatives as potent immunomodulatory agents in tumor microenvironment
Elsevier (2023-11-01)Twenty-seven compounds bearing a tetrazole ring as a central unit have been designed, synthetized and biologically evaluated. Studies have been performed in order to compare the effect of tetrazole derivatives bearing amine ... -
Unveiling the Potential of BenzylethyleneAryl–Urea Scaffolds for the Design of New Onco Immunomodulating Agents
MDPI (2023)This work focuses on the development of thirteen benzylethylenearyl ureas and one carbamate. After the synthesis and purification of the compounds, we studied their antiproliferative action on cell lines, such as HEK-293, ...