Listar por tema "Exemestane"
Mostrando ítems 1-2 de 2
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A theoretical study on the mechanism of the oxidation of substrates by human aromatase enzyme (CYP19A1)
Universitat Jaume I (2016-07-22)The enzyme Cytochrome P450 aromatase plays an essential role in the biosynthesis of estrogens, and its inhibition is an important target for the development of drugs for the treatment of breast cancer. The main purpose of ... -
Theoretical Study of the Mechanism of Exemestane Hydroxylation Catalyzed by Human Aromatase Enzyme
ACS (2016-03)Human aromatase (CYP19A1) aromatizes the androgens to form estrogens via a three-step oxidative process. The estrogens are necessary in humans, mainly in women, because of the role they play in sexual and reproductive ...