Listar por autoría "f6e7647d-e456-4ebf-bbeb-2da19deeff25"
Mostrando ítems 1-11 de 11
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Arylpyridines, arylpyrimidines and related compounds as potential modulator agents of the VEGF, hTERT and c-Myc oncogenes
Martín Beltrán, Celia; Sanchez Peris, Maria; Conesa Milián, Laura; Falomir, Eva; Murga, Juan; Carda, Miguel; Alberto Marco, J. Elsevier (2019-03-01)Twenty-four derivatives structurally related to honokiol have been synthesized and biologically evaluated. IC50 values were determined towards the HT-29, MCF-7 and HEK-293 cell lines. Some of these derivatives exhibited ... -
Furanchalcone–biphenyl hybrids: synthesis, in silico studies, antitrypanosomal and cytotoxic activities
García, Elisa; Ochoa, Rodrigo; Vasquez, Isabel; Conesa Milián, Laura; Carda, Miguel; Yepes, Andrés; Vélez, Iván D.; Robledo, Sara M.; Cardona Galeano, Wilson Isidro Springer Verlag (2019)The synthesis, antitrypanosomal, and cytotoxic activities of 17 furanchalcone derivatives are described herein. The structure of the synthesized products was elucidated by a combination of spectrometric analyses. The ... -
Millorem l’aprenentatge dels alumnes amb metodologies més actives
Conesa Milián, Laura Universitat Jaume I (2015-07-20)El Treball Final de Màster que es presenta en aquest document pertany a la modalitat de Millora Educativa d’acord amb la normativa de TFM de la Universitat Jaume I. En ell es pretén demostrar que la transformació de les ... -
N-alpha-Aminoacyl Colchicines as Promising Anticancer Agents
Marzo Mas, Ana; Conesa Milián, Laura; Noppen, Sam; Liekens, Sandra; Falomir, Eva; Murga, Juan; Carda, Miguel; Marco, J. Alberto Bentham Science Publishers (2020-12-29)Background: In the last years, many efforts have been made to find colchicine derivatives with reduced toxicity. Additionally, the deregulation of amino acid uptake by cancer cells provides an opportunity to improve ... -
Novel multitarget inhibitors with antiangiogenic and immunomodulator properties
Conesa Milián, Laura; Falomir, Eva; Murga, Juan; Carda, Miguel; Marco, J. Alberto Elsevier (2019-03-08)By means of docking studies, seventeen compounds T.1-T17 have been designed and evaluated as multitarget inhibitors of VEGFR-2 and PD-L1 proteins in order to overcome resistance phenomena offered by cancer. All these ... -
Síntesis y evaluación biológica de potenciales agentes anticáncer
Conesa Milián, Laura Universitat Jaume I (2014) -
Synthesis and biological evaluation as antiangiogenic agents of ureas derived from 3′-aminocombretastatin A-4
Conesa Milián, Laura; Falomir, Eva; Murga, Juan; Carda, Miguel; Marco, J. Alberto Elsevier (2019-01-15)Twenty-six compounds derived from 3′-aminocombretastatin A-4 (AmCA-4) containing a urea fragment mimicking the structure of Sorafenib, have been synthesized and evaluated as antiangiogenic compounds. Antiproliferative ... -
Synthesis and biological evaluation of carbamates derived from aminocombretastatin A-4 as vascular disrupting agents
Conesa Milián, Laura; Falomir, Eva; Murga, Juan; Carda, Miguel; Meyen, Eef; Liekens, Sandra; Marco, J. Alberto Elsevier (2018-03-10)A series of t wenty-six carbamates derived from aminocombretastatin A- 4 (AmCA-4 ) were syn thesized and evaluated for their capacity to affect cell proliferation, tubulin polymerization, mitotic cell arrest, microtubule ... -
Synthesis and biological evaluation of simplified pironetin analogues with modifications in the side chain and the lactone ring
Roldán Gómez, Steven; Cardona, Adrià; Conesa Milián, Laura; Murga, Juan; Falomir, Eva; Carda, Miguel; Marco, J. Alberto Royal Society of Chemistry (2017)The preparation of several new analogues of the natural dihydropyrone pironetin is described. They differ from the natural product mainly in the nature of the side chain and the lactone ring. Their cytotoxic activity has ... -
Synthesis and in-vitro evaluation of s-allyl cysteine ester-caffeic acid amide hybrids as potential anticancer agents
Castrillón, Wilson; Herrera-R, Angie; Prieto, Laura Juliana; Conesa Milián, Laura; Carda, Miguel; Naranjo Preciado, Tonny; Maldonado, María Elena; Cardona Galeano, Wilson Isidro Shahid Beheshti University of Medical Sciences, School of Pharmacy (2019)We have synthesized a series of S-allyl cysteine ester-caffeic acid amide hybrids and evaluated them in order to determine their possible anticancer activity and selectivity in colorectal cancer, which is still one of the ... -
Synthesis, In Silico Studies, Antiprotozoal and Cytotoxic Activities of Quinoline‐Biphenyl Hybrids
Coa, Juan Carlos; Yepes, Andrés; Carda, Miguel; Conesa Milián, Laura; Upegui Zapata, Yulieth Alexandra; Robledo, Sara M.; Cardona Galeano, Wilson Isidro Wiley (2020-03-13)The synthesis, in silico studies, antiprotozoal and cytotoxic activities of eleven quinoline‐biphenyl hybrids are described herein. The structure of the synthesized products was elucidated by a combination of spectrometric ...