Listar por autoría "e7198d67-a713-4d7d-89fb-87a1343d98d0"

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    • openAccess   Drosophila Muscleblind Is Involved in troponin T Alternative Splicing and Apoptosis 

      Miranda, M. Eugenia; Zhou, Lei; Artero, Ruben D.; García López, Amparo; Fernández Costa, Juan M.; Pascual, Maya; Vicente Crespo, Marta; Monferrer Sales, Lidón Public Library of Science (PLoS) (2008)
      Background: Muscleblind-like proteins (MBNL) have been involved in a developmental switch in the use of defined cassette exons. Such transition fails in the CTG repeat expansion disease myotonic dystrophy due, in part, ...

    • openAccess   Genetic and Chemical Modifiers Of A CUG Toxicity Model in Drosophila 

      Artero, Ruben D.; Álvarez Abril, María Carmen; Vicente Crespo, Marta; García Alcover, Irma; García López, Amparo; Monferrer Sales, Lidón Public Library of Science (PLoS) (2008)
      Non-coding CUG repeat expansions interfere with the activity of human Muscleblind-like (MBNL) proteins contributing to myotonic dystrophy 1 (DM1). To understand this toxic RNA gain-of-function mechanism we developed a ...