Listar por autoría "dd78e3fe-7b8e-4a3d-95e0-a5122af78edd"
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A Guide to Applying the Sex-Gender Perspective to Nutritional Genomics
Corella, Dolores; Coltell, Oscar; Portolés, Olga; Sotos-Prieto, Mercedes; Fernández-Carrión, Rebeca; Ramírez-Sabio, Judith B.; Zanón-Moreno, Vicente; Mattei, Josiemer; Sorlí, José V; Ordovás Muñoz, José M. MDPI (2019)Precision nutrition aims to make dietary recommendations of a more personalized nature possible, to optimize the prevention or delay of a disease and to improve health. Therefore, the characteristics (including sex) of ... -
Advances in Understanding the Molecular Basis of the Mediterranean Diet Effect
Corella, Dolores; Coltell, Oscar; Macian, Fernando; Ordovás Muñoz, José M. Annual Reviews (2018)Increasingly, studies showing the protective effects of the Mediterranean diet (MedDiet) on different diseases (cardiovascular, diabetes, some cancers, and even total mortality and aging indicators) are being published. ... -
Amino acid change in the carbohydrate response element binding protein is associated with lower triglycerides and myocardial infarction incidence depending on level of adherence to the Mediterranean diet in the PREDIMED trial
CAROLINA, ORTEGA-AZORÍN; Sorlí, José V; Estruch, Ramon; Asensio, Eva Maria; Coltell, Oscar; González, José I.; Martínez González, Miguel Ángel; Ros, Emilio; Salas-Salvadó, Jordi; Fitó, Montserrat; Arós, Fernando; Lapetra, José; Serra-Majem, Lluis; Ruiz-Gutiérrez, Valentina; Gómez Gracia, Enrique; Fiol Ramis, Miquel; Flores, Gemma; Pintó, Xavier; Sáiz, Carmen; Ordovás Muñoz, José M.; Corella, Dolores American Heart Association (2014-02)Background: A variant (rs3812316, C771G, Gln241His) in the MLXIPL (Max-like protein X interacting protein-like) gene encoding the carbohydrate response element binding protein has been associated with lower triglycerides. ... -
APOA2, Dietary Fat, and Body Mass Index: Replication of a Gene-Diet Interaction in 3 Independent Populations
Corella, Dolores; Peloso, Gina; Arnett, Donna K.; Demissie, Serkalem; Cupples, Adrienne; Tucker, Katherine; Lai, Chao-Qiang; Parnell, Laurence D.; Coltell, Oscar; Lee, Yu-Chi; Ordovás Muñoz, José M. American Medical Association (2009-11)For the first time to our knowledge, a gene-diet interaction influencing BMI and obesity has been strongly and consistently replicated in 3 independent populations. -
Association between the APOA2 promoter polymorphism and body weight in Mediterranean and Asian populations: replication of a gene-saturated fat interaction
Corella, Dolores; Tai, E-Shyong; Sorlí, José V; Chew, Suok Kai; Coltell, Oscar; Sotos Prieto, Mercedes; García Ríos, Antonio; Estruch, Ramon; Ordovás Muñoz, José M. Nature Publishing Group (2011-05)Objective: The APOA2 gene has been associated with obesity and insulin resistance (IR) in animal and human studies with controversial results. We have reported an APOA2–saturated fat interaction determining body mass index ... -
Association of the LCT-13910C>T polymorphism with obesity and its modulation by dairy products in a Mediterranean population
Corella, Dolores; Arregui, María; Coltell, Oscar; Portolés, Olga; Guillem Sáiz, Patricia; Carrasco, Paula; Sorlí, José V; CAROLINA, ORTEGA-AZORÍN; González, José I.; Ordovás Muñoz, José M. Nature Publishing Group (2011-08)The -13910C>T polymorphism (rs4988235) upstream from the lactase (LCT) gene, strongly associated with lactase persistence (LP) in Europeans, is emerging as a new candidate for obesity. We aimed to analyze the association ... -
Associations of the FTO rs9939609 and the MC4R rs17782313 polymorphisms with type 2 diabetes are modulate by diet, being higher when adherence to the Mediterranean diet pattern is low
Coltell, Oscar; Martínez González, Miguel Ángel; Salas-Salvadó, Jordi; Arós, Fernando; Lapetra, José; Serra-Majem, Lluis; Gómez Gracia, Enrique; Fiol Ramis, Miquel; Sáez Tormo, Guillermo; Pintó, Xavier; Muñoz, Miguel Ángel; Ordovás Muñoz, José M.; Estruch, Ramon; Corella, Dolores; CAROLINA, ORTEGA-AZORÍN; Sorlí, José V; Asensio, Eva Maria; Covas Planells, María Isabel; Ros, Emilio BioMed Central (2012-11)Background: Although the Fat Mass and Obesity (FTO) and Melanocortin-4 Receptor (MC4R) genes have been consistently associated with obesity risk, the association between the obesity-risk alleles with type 2 diabetes is ... -
Associations of the MCM6-rs3754686 proxy for milk intake in Mediterranean and American populations with cardiovascular biomarkers, disease and mortality: Mendelian randomization
Smith, C.E.; Coltell, Oscar; Sorlí, José V; Estruch, Ramon; Martínez González, Miguel Ángel; Salas-Salvadó, Jordi; Fitó, Montserrat; Arós, Fernando; Dashti, Hassan S.; Lai, Chao-Qiang; Miró, Leticia; Serra-Majem, Lluis; Gómez Gracia, Enrique; Fiol Ramis, Miquel; Ros, Emilio; Aslibekyan, Stella; Hidalgo, Bertha; Neuhouser, Marian L.; Di, Chongzhi; Tucker, Katherine; Arnett, Donna K.; Ordovás Muñoz, José M.; Corella, Dolores Nature Publishing Group (2016)Controversy persists on the association between dairy products, especially milk, and cardiovascular diseases (CVD). Genetic proxies may improve dairy intake estimations, and clarify diet-disease relationships through ... -
Bitter, Sweet, Salty, Sour and Umami Taste Perception Decreases with Age: Sex-Specific Analysis, Modulation by Genetic Variants and Taste-Preference Associations in 18 to 80 Year-Old Subjects
Barragán-Arnal, Rocío; Coltell, Oscar; Portolés, Olga; Asensio, Eva Maria; Sorlí, José V; CAROLINA, ORTEGA-AZORÍN; González, José I.; Sáiz, Carmen; Fernández-Carrión, Rebeca; Ordovás Muñoz, José M.; Corella, Dolores MDPI (2018)There is growing interest in relating taste perception to diet and healthy aging. However, there is still limited information on the influence of age, sex and genetics on taste acuity as well as on the relationship between ... -
CLOCK gene variation is associated with incidence of type-2 diabetes and cardiovascular diseases in type-2 diabetic subjects: dietary modulation in the PREDIMED randomized trial
Corella, Dolores; Asensio, Eva Maria; Coltell, Oscar; Sorlí, José V; Estruch, Ramon; Martínez González, Miguel Ángel; Castañer, Olga; Arós, Fernando; Lapetra, José; Serra-Majem, Lluis; Gómez Gracia, Enrique; CAROLINA, ORTEGA-AZORÍN; Fiol Ramis, Miquel; Díez Espino, Javier; Díaz López, Andrés; Fitó, Montserrat; Ros, Emilio; Ordovás Muñoz, José M. BioMed Central (2016-01)Background Circadian rhythms regulate key biological processes influencing metabolic pathways. Disregulation is associated with type 2 diabetes (T2D) and cardiovascular diseases (CVD). Circadian rhythms are generated by ... -
Education modulates the association of the FTO rs9939609 polymorphism with body mass index and obesity risk in the Mediterranean population
Corella, Dolores; Carrasco, Paula; Sorlí, José V; Coltell, Oscar; CAROLINA, ORTEGA-AZORÍN; Guillen, Montserrat; González, José I.; Sáiz, Carmen; Estruch, Ramon; Ordovás Muñoz, José M. Elsevier (2012)Objective To define whether the rs9939609 FTO (fat mass and obesity associated) single nucleotide polymorphism (SNP) is associated with anthropometric measurements and its modulation by educational level in a Mediterranean ... -
Effects of the Ser326Cys Polymorphism in the DNA Repair OGG1 Gene on Cancer, Cardiovascular, and All-Cause Mortality in the PREDIMED Study: Modulation by Diet
Corella, Dolores; Ramírez-Sabio, Judith B.; Coltell, Oscar; CAROLINA, ORTEGA-AZORÍN; Estruch, Ramon; Martínez González, Miguel Ángel; Salas-Salvadó, Jordi; Sorlí, José V; Castañer, Olga; Arós, Fernando; García-Corte, Franscisco J.; Serra-Majem, Lluis; Gómez-Gracia, Enrique; Fiol Ramis, Miquel; Pintó, Xavier; Sáez, Guillermo T.; Toledo, Estefanía; Basora, Josep; Fitó, Montserrat; Cofán, Montserrat; Ros, Emilio; Ordovás Muñoz, José M. Elsevier (2018-04)Background Oxidatively induced DNA damage, an important factor in cancer etiology, is repaired by oxyguanine glycosylase 1 (OGG1). The lower repair capacity genotype (homozygote Cys326Cys) in the OGG1-rs1052133 (Ser326Cys) ... -
Genome-Wide Association Study (GWAS) on Bilirubin Concentrations in Subjects with Metabolic Syndrome: Sex-Specific GWAS Analysis and Gene-Diet Interactions in a Mediterranean Population
Coltell, Oscar; Asensio, Eva Maria; Sorlí, José V; Barragán-Arnal, Rocío; Fernández-Carrión, Rebeca; Portolés, Olga; CAROLINA, ORTEGA-AZORÍN; Martínez-LaCruz, Raúl; González, José I.; Zanón-Moreno, Vicente; Gimenez Alba, Ignacio Manuel; Fitó, Montserrat; Ros, Emilio; Ordovás Muñoz, José M.; Corella, Dolores MDPI (2019)Although, for decades, increased serum bilirubin concentrations were considered a threatening sign of underlying liver disease and had been associated with neonatal jaundice, data from recent years show that bilirubin is ... -
Mediterranean Diet Reduces the Adverse Effect of the TCF7L2-rs7903146 Polymorphism on Cardiovascular Risk Factors and Stroke Incidence
Corella, Dolores; Carrasco, Paula; Sorlí, José V; Estruch, Ramon; Rico Sanz, Jesús; Martínez González, Miguel Ángel; Salas-Salvadó, Jordi; Covas Planells, María Isabel; Coltell, Oscar; Arós, Fernando; Lapetra, José; Serra-Majem, Lluis; Ruiz-Gutiérrez, Valentina; Warnberg, Julia; Fiol Ramis, Miquel; Pintó, Xavier; CAROLINA, ORTEGA-AZORÍN; Muñoz, Miguel Ángel; Martínez, J. Alfredo; Gómez Gracia, Enrique; González, José I.; Ros, Emilio; Ordovás Muñoz, José M. American Diabetes Association (2013)OBJECTIVE Transcription factor 7-like 2 (TCF7L2) polymorphisms are strongly associated with type 2 diabetes, but controversially with plasma lipids and cardiovascular disease. Interactions of the Mediterranean diet (MedDiet) ... -
MicroRNA-410 regulated lipoprotein lipase variant rs13702 is associated with stroke incidence and modulated by diet in the randomized controlled PREDIMED trial
Corella, Dolores; Sorlí, José V; Estruch, Ramon; Coltell, Oscar; CAROLINA, ORTEGA-AZORÍN; Portolés, Olga; Martínez González, Miguel Ángel; Bulló, Mònica; Fitó, Montserrat; Arós, Fernando; Lapetra, José; Asensio, Eva Maria; Sáez Tormo, Guillermo; Serra-Majem, Lluis; Muñoz Bravo, Carlos; Ruiz-Gutiérrez, Valentina; Fiol Ramis, Miquel; Vinyoles, Ernest; Pintó, Xavier; Richardson, Kris; Ros, Emilio; Ordovás Muñoz, José M. American Society for Nutrition (2014-08)Background: MicroRNAs have emerged as important epigenetic regulators in cardiovascular diseases (CVDs). Using an observational meta-analysis design, we previously characterized a gain-of-function microRNA-410 target site ... -
MicroRNAs and Drinking: Association between the Pre-miR-27a rs895819 Polymorphism and Alcohol Consumption in a Mediterranean Population
Barragán-Arnal, Rocío; Coltell, Oscar; Asensio, Eva Maria; Francés, Francesc; Sorlí, José V; Estruch, Ramon; Salas Huetos, Albert; Ordovás Muñoz, José M.; Corella, Dolores MDPI (2016)Recently, microRNAs (miRNA) have been proposed as regulators in the different processes involved in alcohol intake, and differences have been found in the miRNA expression profile in alcoholics. However, no study has ... -
Novel association of the obesity risk-allele near Fas Apoptotic Inhibitory Molecule 2 (FAIM2) gene with heart rate and study of its effects on myocardial infarction in diabetic participants of the PREDIMED trial
Corella, Dolores; Sorlí, José V; González, José I.; CAROLINA, ORTEGA-AZORÍN; Fitó, Montserrat; Bulló, Mònica; Martínez González, Miguel Ángel; Ros, Emilio; Arós, Fernando; Lapetra, José; Gómez Gracia, Enrique; Serra-Majem, Lluis; Ruiz-Gutiérrez, Valentina; Fiol Ramis, Miquel; Coltell, Oscar; Vinyoles, Ernest; Pintó, Xavier; Martí, Amelia; Sáiz, Carmen; Ordovás Muñoz, José M.; Estruch, Ramon BioMed Central (2014-01)Background: The Fas apoptotic pathway has been implicated in type 2 diabetes and cardiovascular disease. Although a polymorphism (rs7138803; G > A) near the Fas apoptotic inhibitory molecule 2 (FAIM2) locus has been related ... -
Nutrigenética, nutrigenómica y dieta mediterránea: una nueva visión para la gastronomía
Corella, Dolores; Barragán-Arnal, Rocío; Ordovás Muñoz, José M.; Coltell, Oscar Arán Ediciones (2018)Tanto la nutrigenética como la nutrigenómica son disciplinas dentro de la denominada genómica nutricional, que, en sentido amplio, proporciona el marco de integración de las distintas ómicas con las ciencias de la ... -
Polymorphism of the Transcription Factor 7-Like 2 Gene (TCF7L2) Interacts with Obesity on Type-2 Diabetes in the PREDIMED Study Emphasizing the Heterogeneity of Genetic Variants in Type-2 Diabetes Risk Prediction: Time for Obesity-Specific Genetic Risk Scores
Corella, Dolores; Coltell, Oscar; Sorlí, José V; Estruch, Ramon; Quiles Guiñau, Laura; Martínez González, Miguel Ángel; Salas-Salvadó, Jordi; Castañer, Olga; Arós, Fernando; Ortega-Calvo, Manuel; Serra-Majem, Lluis; Gómez Gracia, Enrique; Portolés, Olga; Fiol Ramis, Miquel; Díez Espino, Javier; Basora, Josep; Fitó, Montserrat; Ros, Emilio; Ordovás Muñoz, José M. MDPI (2016)Nutrigenetic studies analyzing gene–diet interactions of the TCF7L2-rs7903146 C > T polymorphism on type-2 diabetes (T2D) have shown controversial results. A reason contributing to this may be the additional modulation by ... -
Statistical and biological gene-lifestyle interactions of MC4R and FTO with Diet and physical activity on obesity: new effects on alcohol consumption
Corella, Dolores; CAROLINA, ORTEGA-AZORÍN; Sorlí, José V; Covas Planells, María Isabel; Carrasco, Paula; Salas-Salvadó, Jordi; Martínez González, Miguel Ángel; Arós, Fernando; Lapetra, José; Serra-Majem, Lluis; Lamuela Raventós, Rosa María; Gómez García, Enrique; Fiol Ramis, Miquel; Pintó, Xavier; Ros, Emilio; Martí, Amelia; Coltell, Oscar; Ordovás Muñoz, José M.; Estruch, Ramon Public Library of Science (2012)Background: Fat mass and obesity (FTO) and melanocortin-4 receptor (MC4R) and are relevant genes associated with obesity. This could be through food intake, but results are contradictory. Modulation by diet or other ...