Listar por autoría "c1e0bfa4-1075-482b-a7f4-59123bfe431a"
Mostrando ítems 1-8 de 8
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Co-assembly of tetrapeptides into complex pH-responsive molecular hydrogel networks
Tena Solsona, Marta; Alonso de Castro, S.; Miravet, Juan; Escuder, Beatriu Royal Society of Chemistry (2014-07)Here we prepare pH-responsive complex molecular hydrogels from oppositely charged tetrapeptidic components that can be pH-tuned resulting in interconversion between different networks. Two different systems are described ... -
Mechanistic Insight into the Lability of the Benzyloxycarbonyl (Z) Group inN-Protected Peptides under Mild Basic Conditions
Tena Solsona, Marta; Angulo-Pachón, César A.; Escuder, Beatriu; Miravet, Juan Wiley Online Library (2014)The unexpected lability of Z protecting group under mild basic conditions at room temperature is explained by a mechanism based on anchimeric assistance. It is found that the vicinal amide group stabilizes the tetrahedral ... -
Self-assembled hybrid hydrogels based on an amphipathic low molecular weight peptide derivative and a water-soluble poly(para-phenylene vinylene)
RUBIO-MAGNIETO, JENIFER; Tena Solsona, Marta; Escuder, Beatriu; Surin, Mathieu Royal Society of Chemistry (2017)The self-assembly of an amphipathic low molecular weight peptide and a water-soluble p-conjugated polyelectrolyte is studied in order to form hybrid hydrogel materials with synergistic properties. The self-assembly of ... -
Self-assembled multivalent (SAMul) ligand systems with enhanced stability in the presence of human serum
Tena Solsona, Marta; Marson, Domenico; Rodrigo, Ana C.; Bromfield, Stephen M.; Escuder, Beatriu; Miravet, Juan; Apostolova, Nadezda; Laurini, Erik; Pricl, Sabrina Royal Society of Chemistry (2019)Self-assembled cationic micelles are an attractive platform for binding biologically-relevant polyanions such as heparin. This has potential applications in coagulation control, where a synthetic heparin rescue agent could ... -
Self-assembly of a peptide amphiphile: transition from nanotape fibrils to micelles
Miravet, Juan; Escuder, Beatriu; Segarra Maset, María Dolores; Tena Solsona, Marta; Hamley, Ian W.; Dehsorkhi, Ashkan; Castelletto, Valeria Royal Society of Chemistry (2013-02)A thermal transition is observed in the peptide amphiphile C16-KTTKS (TFA salt) from nanotapes at 20 °C to micelles at higher temperature (the transition temperature depending on concentration). The formation of extended ... -
Tetrapeptidic Molecular Hydrogels: Self-assembly and Co-aggregation with Amyloid Fragment Aβ1-40
Tena Solsona, Marta; Miravet, Juan; Escuder, Beatriu WILEY-VCH Verlag GmbH & Co. KGaA (2014-01)A new family of isomeric tetrapeptides containing aromatic and polar amino acid residues that are able to form molecular hydrogels following a smooth change in pH is described. The hydrogels have been studied by spectroscopic ... -
Thermodynamic and Kinetic Study of the Fibrillization of a Family of Tetrapeptides and Its Application to Self-Sorting. What Takes So Long?
Tena Solsona, Marta; Escuder, Beatriu; Miravet, Juan; Castelletto, Valeria; Hamley, Ian W.; Dehsorkhi, Ashkan American Chemical Society (2015-04-13)Insight is provided into the thermodynamics and kinetics of peptide fibrillization, a process of particular interest in biomedicine due to its direct relationship to amyloid diseases. The studied isomeric tetrapeptides are ... -
Towards Supramolecular Catalysis with Small Self-assembled Peptides
Singh, Nishant; Tena Solsona, Marta; Miravet, Juan; Escuder, Beatriu Wiley-VCH Verlag (2015-04)Self-assembly of small peptides offers unique opportunities for the bottom-up construction of supramolecular catalysts that aim to emulate the efficiency and selectivity of natural enzymes. Small, information-rich, simple ...