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The purine analogues abacavir and didanosine increase acetaminophen-induced hepatotoxicity by enhancing mitochondrial dysfunction
Blas García, Ana; Martí Rodrigo, Alberto; Víctor, Víctor M.; Polo, Míriam; Alegre, Fernando; Funes, Haryes A.; Apostolova, Nadezda; Esplugues Mota, Juan V. Oxford University Press (2016-01-07)Background NRTIs are essential components of HIV therapy with well-documented, long-term mitochondrial toxicity in hepatic cells, but whose acute effects on mitochondria are unclear. As acetaminophen-induced hepatotoxicity ...