• openAccess   Revealing the mechanism for covalent inhibition of glycoside hydrolases by carbasugars at an atomic level 

      Ren, Weiwu; Pengelly, Robert; Farren-Dai, Marco; Shamsi Kazem Abadi, Saeideh; Oehler, Verena; Akintola, Oluwafemi; Draper, Jason; Meanwell, Michael; Chakladar, Saswati; Świderek, Katarzyna; Moliner, Vicent; Britton, Robert; Gloster, Tracey M.; Bennet, Andrew J. Nature Research (2018)
      Mechanism-based glycoside hydrolase inhibitors are carbohydrate analogs that mimic the natural substrate’s structure. Their covalent bond formation with the glycoside hydrolase makes these compounds excellent tools for ...