Listar por autoría "99212291-ef3d-4018-a3b0-15ae92c575a0"
Mostrando ítems 1-3 de 3
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Cytokines and chemokines as biomarkers of ethanol-induced neuroinflammation and anxiety-related behavior: Role of TLR4 and TLR2
Pascual, María; Baliño, Pablo; González Aragón, Carlos Manuel; Guerri, Consuelo Springer (2015)Recent evidence supports the influence of neuroimmune system activation on behavior. We have demonstrated that ethanol activates the innate immune system by stimulating toll-like receptor 4 (TLR4) signaling in glial cells, ... -
Impact of TLR4 on behavioral and cognitive dysfunctions associated with alcohol-induced neuroinflammatory damage
Pascual, María; Baliño, Pablo; Alfonso Loeches, Silvia; González Aragón, Carlos Manuel; Guerri, Consuelo Elsevier (2011-06-01)Toll-like receptors (TLRs) play an important role in the innate immune response, and emerging evidence indicates their role in brain injury and neurodegeneration. Our recent results have demonstrated that ethanol is capable ... -
Induction of brain cytochrome P450 2E1 boosts the locomotor-stimulating effects of ethanol in mice
Ledesma Llorente, Juan Carlos; MIQUEL, MARTA; Pascual, María; Guerri, Consuelo; González Aragón, Carlos Manuel Elsevier (2014)In the central nervous system ethanol (EtOH) is metabolized into acetaldehyde by different enzymes. Brain catalase accounts for 60% of the total production of EtOH-derived acetaldehyde, whereas cerebral cytochrome P450 2E1 ...