• openAccess   A Lower Olfactory Capacity Is Related to Higher Circulating Concentrations of Endocannabinoid 2-Arachidonoylglycerol and Higher Body Mass Index in Women 

      Pastor, Antoni; Fernández Aranda, Fernando; Fitó, Montserrat; Jiménez-Murcia, Susana; Botella, Cristina; Fernández-Real, José Manuel; Frühbeck, Gema; Tinahones Madueño, Francisco Javier; Fagundo, Ana B.; Rodriguez, Joan; Agüera, Zaida; Langohr, Klaus; Casanueva, Felipe F.; De la Torre, Rafael Public Library of Science (2016-02)
      The endocannabinoid (eCB) system can promote food intake by increasing odor detection in mice. The eCB system is over-active in human obesity. Our aim is to measure circulating eCB concentrations and olfactory capacity in ...
    • openAccess   Amino acid change in the carbohydrate response element binding protein is associated with lower triglycerides and myocardial infarction incidence depending on level of adherence to the Mediterranean diet in the PREDIMED trial 

      CAROLINA, ORTEGA-AZORÍN; Sorlí, José V; Estruch, Ramon; Asensio, Eva Maria; Coltell, Oscar; González, José I.; Martínez González, Miguel Ángel; Ros, Emilio; Salas-Salvadó, Jordi; Fitó, Montserrat; Arós, Fernando; Lapetra, José; Serra-Majem, Lluis; Ruiz-Gutiérrez, Valentina; Gómez Gracia, Enrique; Fiol Ramis, Miquel; Flores, Gemma; Pintó, Xavier; Sáiz, Carmen; Ordovás Muñoz, José M.; Corella, Dolores American Heart Association (2014-02)
      Background: A variant (rs3812316, C771G, Gln241His) in the MLXIPL (Max-like protein X interacting protein-like) gene encoding the carbohydrate response element binding protein has been associated with lower triglycerides. ...
    • openAccess   Association between dietary fibre intake and fruit, vegetable or whole-grain consumption and the risk of CVD: results from the PREvención con DIeta MEDiterránea (PREDIMED) trial 

      Buil-Cosiales, Pilar; Toledo, Estefanía; Salas-Salvadó, Jordi; Zazpe, Itziar; Farràs, Marta; Basterra-Gortari, Francisco Javier; Díez Espino, Javier; Estruch, Ramon; Corella, Dolores; Ros, Emilio; Marti, Amelia; Gómez Gracia, Enrique; Ortega-Calvo, Manuel; Arós, Fernando; Moñino, Manuel; Serra-Majem, Lluis; Pintó, Xavier; Lamuela Raventós, Rosa María; Babio, Nancy; González, José I.; Fitó, Montserrat; Martínez González, Miguel Ángel Nutrition Society (2016)
      Prospective studies assessing the association between fibre intake or fibre-rich food consumption and the risk of CVD have often been limited by baseline assessment of diet. Thus far, no study has used yearly repeated ...
    • openAccess   Associations of the MCM6-rs3754686 proxy for milk intake in Mediterranean and American populations with cardiovascular biomarkers, disease and mortality: Mendelian randomization 

      Smith, C.E.; Coltell, Oscar; Sorlí, José V; Estruch, Ramon; Martínez González, Miguel Ángel; Salas-Salvadó, Jordi; Fitó, Montserrat; Arós, Fernando; Dashti, Hassan S.; Lai, Chao-Qiang; Miró, Leticia; Serra-Majem, Lluis; Gómez Gracia, Enrique; Fiol Ramis, Miquel; Ros, Emilio; Aslibekyan, Stella; Hidalgo, Bertha; Neuhouser, Marian L.; Di, Chongzhi; Tucker, Katherine; Arnett, Donna K.; Ordovás Muñoz, José M.; Corella, Dolores Nature Publishing Group (2016)
      Controversy persists on the association between dairy products, especially milk, and cardiovascular diseases (CVD). Genetic proxies may improve dairy intake estimations, and clarify diet-disease relationships through ...
    • openAccess   CLOCK gene variation is associated with incidence of type-2 diabetes and cardiovascular diseases in type-2 diabetic subjects: dietary modulation in the PREDIMED randomized trial 

      Corella, Dolores; Asensio, Eva Maria; Coltell, Oscar; Sorlí, José V; Estruch, Ramon; Martínez González, Miguel Ángel; Castañer, Olga; Arós, Fernando; Lapetra, José; Serra-Majem, Lluis; Gómez Gracia, Enrique; CAROLINA, ORTEGA-AZORÍN; Fiol Ramis, Miquel; Díez Espino, Javier; Díaz López, Andrés; Fitó, Montserrat; Ros, Emilio; Ordovás Muñoz, José M. BioMed Central (2016-01)
      Background Circadian rhythms regulate key biological processes influencing metabolic pathways. Disregulation is associated with type 2 diabetes (T2D) and cardiovascular diseases (CVD). Circadian rhythms are generated by ...
    • closedAccess   Cohort Profile: Design and methods of the PREDIMED-Plus randomized trial 

      Martínez González, Miguel Ángel; Buil-Cosiales, Pilar; Corella, Dolores; Bulló, Mònica; Fitó, Montserrat; Vioque, Jesus; Romaguera, Dora; Martínez, J. Alfredo; Wärnberg, Julia; López Miranda, José; Estruch, Ramon; Bueno Cavanillas, Aurora; Arós, Fernando; Tur, Josep; Tinahones Madueño, Francisco José; Serra-Majem, Lluis; Martín, Vicente; Lapetra, José; Vázquez, Clotilde; Pintó, Xavier; Vidal, Josep; Daimiel-Ruiz, Lidia Ángeles; Delgado Rodríguez, Miguel; Matía, Pilar; Ros, Emilio; Fernández Aranda, Fernando; Botella, Cristina; Puy Portillo-Baquedano, María; Lamuela Raventós, Rosa María; Marcos, Ascensión; Sáez, Guillermo; Gómez-Gracia, Enrique; Ruiz-Canela, Miguel; Toledo, Estefanía; Alvarez-Alvarez, Ismael; Díez Espino, Javier; Sorlí, José V; Basora, Josep; Castañer, Olga; Schröder, Helmut; Navarrete-Muñoz, Eva María; Zulet, M. Angeles; García-Rios, Antonio; Salas-Salvadó, Jordi Oxford University Press (2019-04)
      The PREDIMED (in Spanish: PREvención con DIeta MEDiterránea) primary prevention trial1–3 reported in 2013 that long-term adherence to an energy-unrestricted Mediterranean diet (MedDiet), supplemented with either extra-virgin ...
    • openAccess   Dietary alpha-Linolenic Acid, Marine omega-3 Fatty Acids, and Mortality in a Population With High Fish Consumption: Findings From the PREvención con DIeta MEDiterránea (PREDIMED) Study 

      Sala-Vila, Aleix; Guash-Ferré, Marta; Hu, Frank B.; Sánchez-Tainta, Ana; Bulló, Mònica; Serra-Mir, Mercè; López-Sabater, Maria Carmen; Sorlí, José V; Arós, Fernando; Fiol Ramis, Miquel; Muñoz, Miguel Ángel; Serra-Majem, Lluis; Martínez, J. Alfredo; Corella, Dolores; Fitó, Montserrat; Salas-Salvadó, Jordi; Martínez González, Miguel Ángel; Estruch, Ramon; Ros, Emilio; Coltell, Oscar; PREDIMED Investigators American Heart Association (2016-01)
      Background Epidemiological evidence suggests a cardioprotective role of α‐linolenic acid (ALA), a plant‐derived ω‐3 fatty acid. It is unclear whether ALA is beneficial in a background of high marine ω‐3 fatty acids (long‐chain ...
    • openAccess   Effects of the Ser326Cys Polymorphism in the DNA Repair OGG1 Gene on Cancer, Cardiovascular, and All-Cause Mortality in the PREDIMED Study: Modulation by Diet 

      Corella, Dolores; Ramírez-Sabio, Judith B.; Coltell, Oscar; CAROLINA, ORTEGA-AZORÍN; Estruch, Ramon; Martínez González, Miguel Ángel; Salas-Salvadó, Jordi; Sorlí, José V; Castañer, Olga; Arós, Fernando; García-Corte, Franscisco J.; Serra-Majem, Lluis; Gómez-Gracia, Enrique; Fiol Ramis, Miquel; Pintó, Xavier; Sáez, Guillermo T.; Toledo, Estefanía; Basora, Josep; Fitó, Montserrat; Cofán, Montserrat; Ros, Emilio; Ordovás Muñoz, José M. Elsevier (2018-04)
      Background Oxidatively induced DNA damage, an important factor in cancer etiology, is repaired by oxyguanine glycosylase 1 (OGG1). The lower repair capacity genotype (homozygote Cys326Cys) in the OGG1-rs1052133 (Ser326Cys) ...
    • closedAccess   Frequent Consumption of Sugar- and Artificially Sweetened Beverages and Natural and Bottled Fruit Juices Is Associated with an Increased Risk of Metabolic Syndrome in a Mediterranean Population at High Cardiovascular Disease Risk 

      Ferreira-Pêgo, Cíntia; Babio, Nancy; Bes-Rastrollo, Maira; Corella, Dolores; Estruch, Ramon; Ros, Emilio; Fitó, Montserrat; Serra-Majem, Lluis; Arós, Fernando; Fiol Ramis, Miquel; Santos Lozano, José Manuel; Muñoz-Bravo, Carlos; Pintó, Xavier; Ruiz-Canela, Miguel; Salas-Salvadó, Jordi; Coltell, Oscar American Society for Nutrition (2016-08)
      Background: The relation between the consumption of sweetened beverages and metabolic syndrome (MetS) is controversial. Objective: This analysis evaluated the associations between intakes of sugar-sweetened beverages ...
    • openAccess   Genome-Wide Association Study (GWAS) on Bilirubin Concentrations in Subjects with Metabolic Syndrome: Sex-Specific GWAS Analysis and Gene-Diet Interactions in a Mediterranean Population 

      Coltell, Oscar; Asensio, Eva Maria; Sorlí, José V; Barragán-Arnal, Rocío; Fernández-Carrión, Rebeca; Portolés, Olga; CAROLINA, ORTEGA-AZORÍN; Martínez-LaCruz, Raúl; González, José I.; Zanón-Moreno, Vicente; Gimenez Alba, Ignacio Manuel; Fitó, Montserrat; Ros, Emilio; Ordovás Muñoz, José M.; Corella, Dolores MDPI (2019)
      Although, for decades, increased serum bilirubin concentrations were considered a threatening sign of underlying liver disease and had been associated with neonatal jaundice, data from recent years show that bilirubin is ...
    • closedAccess   In vivo transcriptomic profile after a Mediterranean diet in high–cardiovascular risk patients: a randomized controlled trial 

      Castañer, Olga; Corella, Dolores; Covas Planells, María Isabel; Subirana, Isaac; Flores Mateo, Gemma; Nonell, Lara; Bulló, Mònica; De la Torre, Rafael; Portolés, Olga; Fitó, Montserrat American Society for Nutrition (2013)
      Background: Nutrients can exert healthy effects through nutrigenomic modulation. Data are scarce concerning the in vivo effect of a sustained traditional Mediterranean diet (TMD) pattern on the whole transcriptomic ...
    • closedAccess   Intake of Total Polyphenols and Some Classes of Polyphenols Is Inversely Associated with Diabetes in Elderly People at High Cardiovascular Disease Risk 

      Tresserra-Rimbau, Anna; Guash-Ferré, Marta; Salas-Salvadó, Jordi; Toledo, Estefanía; Corella, Dolores; Castañer, Olga; Guo, Xiaohui; Gómez Gracia, Enrique; Lapetra, José; Arós, Fernando; Fiol Ramis, Miquel; Ros, Emilio; Serra-Majem, Lluis; Pintó, Xavier; Fitó, Montserrat; Babio, Nancy; Martínez González, Miguel Ángel; Sorlí, José V; López-Sabater, Maria Carmen; Estruch, Ramon; Lamuela Raventós, Rosa María; Coltell, Oscar; PREDIMED Investigators American Society for Nutrition (2016-03)
      Background: Higher consumption of some polyphenols has been associated with a reduced risk of diabetes. However, no studies have evaluated the relation between all polyphenol subclasses and the incidence of diabetes. Objective: ...
    • closedAccess   MicroRNA-410 regulated lipoprotein lipase variant rs13702 is associated with stroke incidence and modulated by diet in the randomized controlled PREDIMED trial 

      Corella, Dolores; Sorlí, José V; Estruch, Ramon; Coltell, Oscar; CAROLINA, ORTEGA-AZORÍN; Portolés, Olga; Martínez González, Miguel Ángel; Bulló, Mònica; Fitó, Montserrat; Arós, Fernando; Lapetra, José; Asensio, Eva Maria; Sáez Tormo, Guillermo; Serra-Majem, Lluis; Muñoz Bravo, Carlos; Ruiz-Gutiérrez, Valentina; Fiol Ramis, Miquel; Vinyoles, Ernest; Pintó, Xavier; Richardson, Kris; Ros, Emilio; Ordovás Muñoz, José M. American Society for Nutrition (2014-08)
      Background: MicroRNAs have emerged as important epigenetic regulators in cardiovascular diseases (CVDs). Using an observational meta-analysis design, we previously characterized a gain-of-function microRNA-410 target site ...
    • openAccess   Novel association of the obesity risk-allele near Fas Apoptotic Inhibitory Molecule 2 (FAIM2) gene with heart rate and study of its effects on myocardial infarction in diabetic participants of the PREDIMED trial 

      Corella, Dolores; Sorlí, José V; González, José I.; CAROLINA, ORTEGA-AZORÍN; Fitó, Montserrat; Bulló, Mònica; Martínez González, Miguel Ángel; Ros, Emilio; Arós, Fernando; Lapetra, José; Gómez Gracia, Enrique; Serra-Majem, Lluis; Ruiz-Gutiérrez, Valentina; Fiol Ramis, Miquel; Coltell, Oscar; Vinyoles, Ernest; Pintó, Xavier; Martí, Amelia; Sáiz, Carmen; Ordovás Muñoz, José M.; Estruch, Ramon BioMed Central (2014-01)
      Background: The Fas apoptotic pathway has been implicated in type 2 diabetes and cardiovascular disease. Although a polymorphism (rs7138803; G > A) near the Fas apoptotic inhibitory molecule 2 (FAIM2) locus has been related ...
    • openAccess   Polymorphism of the Transcription Factor 7-Like 2 Gene (TCF7L2) Interacts with Obesity on Type-2 Diabetes in the PREDIMED Study Emphasizing the Heterogeneity of Genetic Variants in Type-2 Diabetes Risk Prediction: Time for Obesity-Specific Genetic Risk Scores 

      Corella, Dolores; Coltell, Oscar; Sorlí, José V; Estruch, Ramon; Quiles Guiñau, Laura; Martínez González, Miguel Ángel; Salas-Salvadó, Jordi; Castañer, Olga; Arós, Fernando; Ortega-Calvo, Manuel; Serra-Majem, Lluis; Gómez Gracia, Enrique; Portolés, Olga; Fiol Ramis, Miquel; Díez Espino, Javier; Basora, Josep; Fitó, Montserrat; Ros, Emilio; Ordovás Muñoz, José M. MDPI (2016)
      Nutrigenetic studies analyzing gene–diet interactions of the TCF7L2-rs7903146 C > T polymorphism on type-2 diabetes (T2D) have shown controversial results. A reason contributing to this may be the additional modulation by ...
    • openAccess   Polyphenol intake from a Mediterranean dietdecreases inflammatory biomarkers related toatherosclerosis: a substudy of the PREDIMED trial 

      Medina Remón, A.; Casas, Rosa; Tresserra-Rimbau, Anna; Ros, Emilio; Martínez González, Miguel Ángel; Fitó, Montserrat; Corella, Dolores; Salas-Salvadó, Jordi; Lamuela Raventós, Rosa María; Estruch, Ramon; PREDIMED Investigators (2017)
      High dietary polyphenol intake is associated with reduced all-cause mortality and a lower incidence of cardiovascular events. However, the mechanisms involved are not fully understood. The aim of the present substudy of ...
    • closedAccess   PREDIMED Investigators 

      Díez Espino, Javier; Basterra-Gortari, Francisco Javier; Salas-Salvadó, Jordi; Buil-Cosiales, Pilar; Corella, Dolores; Schröder, Helmut; Estruch, Ramon; Ros, Emilio; Gómez-Gracia, Enrique; Arós, Fernando; Fiol Ramis, Miquel; Lapetra, José; Serra-Majem, Lluis; Pintó, Xavier; Babio, Nancy; Quiles Guiñau, Laura; Fitó, Montserrat; Marti, Amelia; Toledo, Estefanía; PREDIMED Investigators Elsevier (2017)
      Background Eggs are a major source of dietary cholesterol and their consumption has been sometimes discouraged. A relationship between egg consumption and the incidence of cardiovascular disease (CVD) has been suggested ...
    • openAccess   Total and Subtypes of Dietary Fat Intake and Its Association with Components of the Metabolic Syndrome in a Mediterranean Population at High Cardiovascular Risk 

      Julibert, Alicia; Bibiloni, Maria del Mar; Bouzas Velasco, Cristina; Martínez González, Miguel Ángel; Salas-Salvadó, Jordi; Corella, Dolores; Zomeño, Maria Dolors; Romaguera, Dora; Vioque, Jesus; Alonso-Gómez, Ángel M.; Wärnberg, Julia; Martínez, J. Alfredo; Serra-Majem, Lluis; Estruch, Ramon; Tinahones, Francisco J.; Lapetra, José; Pintó, Xavier; López Miranda, José; García-Molina, Laura; Gaforio, Jose J; Matía-Martín, Pilar; Daimiel-Ruiz, Lidia Ángeles; Martín Sánchez, Vicente; Vidal, Josep; Vázquez, Clotilde; Ros, Emili; Toledo, Estefanía; Becerra-Tomás, Nerea; Portolés, Olga; Pérez-Vega, Karla A.; Fiol Ramis, Miquel; Torres-Collado, Laura; Tojal-Sierra, Lucas; Carabaño-Moral, Rosa; Abete, Itziar; Sanchez Villegas, Almudena; Casas, Rosa; Bernal López, María Rosa; Santos Lozano, José Manuel; Galera, Ana; Ugarriza, Lucía; Ruiz-Canela, Miguel; Babio, Nancy; Coltell, Oscar; Schröder, Helmut; Konieczna, Jadwiga; Orozco Beltrán, Domingo; Sorto-Sánchez, Carolina; Eguaras, Sonia; Barrubés, Laura; Fitó, Montserrat; Tur, Josep A.; PREDIMED-PLUS Investigators MDPI (2019)
      Background: The effect of dietary fat intake on the metabolic syndrome (MetS) and in turn on cardiovascular disease (CVD) remains unclear in individuals at high CVD risk. Objective: To assess the association between fat ...
    • openAccess   Transdiagnostic perspective of impulsivity and compulsivity in obesity: from cognitive profile to self-reported dimensions in clinical samples with and without diabetes 

      Testa, Giulia; Mora, Bernat; Camacho-Barcia, Lucía; Granero, Roser; Lucas, Ignacio; Agüera, Zaida; Jiménez-Murcia, Susana; Baños, Rosa Maria; Bertaina-Anglade, Valerie; Botella, Cristina; Bulló, Mònica; Casanueva, Felipe F.; Dalsgaard, Søren; Fernández-Real, José Manuel; Franke, Barbara; Frühbeck, Gema; Fitó, Montserrat; Gómez Martínez, Carlos; Pintó, Xavier; Poelmans, Geert; Tinahones, Francisco J; De la Torre, Rafael; Salas-Salvadó, Jordi; Serra-Majem, Lluis; Vos, Stephanie; Wimberley, Theresa; Fernández Aranda, Fernando MDPI (2021-12-10)
      Impulsive and compulsive behaviors have both been observed in individuals with obesity. The co-occurrence of obesity and type 2 diabetes (T2D) is more strongly associated with impulsivity, although there are no conclusive ...