Listar por autoría "74697966-557e-4c6e-80b5-3625b08769ee"
Mostrando ítems 1-6 de 6
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Channel-Inactivating Mutations and Their Revertant Mutants in the Envelope Protein of Infectious Bronchitis Virus
To, Janet; Surya, Wahyu; To, Sing Fung; Li, Yan; Verdiá Báguena, Carmen; Queralt-Martín, María; Aguilella, Vicente; Ding, Xiang Liu; Torres, Jaume American Society for Microbiology (2016-12)It has been shown previously in the severe acute respiratory syndrome coronavirus (SARS-CoV) that two point mutations, N15A and V25F, in the transmembrane domain (TMD) of the envelope (E) protein abolished channel activity ... -
Coronavirus E protein forms ion channels with functionally and structurally-involved membrane lipids
Aguilella, Vicente; Alcaraz, Antonio; Verdiá Báguena, Carmen; Nieto Torres, José L.; De Diego, Marta L.; Torres, Jaume; Enjuanes, Luis Elsevier (2012-10)Coronavirus (CoV) envelope (E) protein ion channel activity was determined in channels formed in planar lipid bilayers by peptides representing either the transmembrane domain of severe acute respiratory syndrome CoV ... -
Inhibition of the human respiratory syncytial virus small hydrophobic protein and structural variations in a bicelle environment
Li, Yan; To, Janet; Verdiá Báguena, Carmen; Dossena, Silvia; Surya, Wahyu; Huang, Mei; Paulmichl, Markus; Liu, Ding Xiang; Aguilella, Vicente; Torres, Jaume American Society for Microbiology (2014)The small hydrophobic (SH) protein is a 64-amino-acid polypeptide encoded by the human respiratory syncytial virus (hRSV). SH protein has a single α-helical transmembrane (TM) domain that forms pentameric ion channels. ... -
MERS coronavirus envelope protein has a single transmembrane domain that forms pentameric ion channels
Surya, Wahyu; Li, Yan; Verdiá Báguena, Carmen; Aguilella, Vicente; Torres, Jaume Elsevier (2015-04)The Middle East respiratory syndrome coronavirus (MERS-CoV) is a newly identified pathogen able of human transmission that causes a mortality of almost 40%. As in the case of SARS-CoV, MERS virus lacking E protein represents ... -
Severe acute respiratory syndrome coronavirus E protein transports calcium ions and activates the NLRP3 inflammasome
Nieto Torres, José L.; Verdiá Báguena, Carmen; Jiménez Guardeño, José M.; Regla Nava, José A.; Castaño Rodríguez, Carlos; Fernández Delgado, Raúl; Torres, Jaume; Aguilella, Vicente; Enjuanes, Luis Elsevier (2015-11)Severe acute respiratory syndrome coronavirus (SARS-CoV) envelope (E) protein is a viroporin involved in virulence. E protein ion channel (IC) activity is specifically correlated with enhanced pulmonary damage, edema ... -
Severe Acute Respiratory Syndrome Coronavirus Envelope Protein Ion Channel Activity Promotes Virus Fitness and Pathogenesis
Nieto Torres, José L.; De Diego, Marta L.; Verdiá Báguena, Carmen; Jiménez Guardeño, José M.; Regla Nava, José A.; Fernández Delgado, Raúl; Castaño Rodríguez, Carlos; Alcaraz, Antonio; Torres, Jaume; Aguilella, Vicente; Enjuanes, Luis Public Library of Science (2014)Deletion of Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV) envelope (E) gene attenuates the virus. E gene encodes a small multifunctional protein that possesses ion channel (IC) activity, an important function ...