Listar por autoría "6b30e3e1-75fa-460f-bcb8-589ebf5cf29d"
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Acetate as an active metabolite of ethanol: studies of locomotion, loss of righting reflex, and anxiety in rodents
Pardo Andrés, Marta; Betz, Adrienne J.; San Miguel Segura, Noemí; López Cruz, Laura; Salamone, John; Correa, Merce Frontiers (2013)It has been postulated that a number of the central effects of ethanol are mediated via ethanol metabolites: acetaldehyde and acetate. Ethanol is known to produce a large variety of behavioral actions such anxiolysis, ... -
Activational and effort-related aspects of motivation: neural mechanisms and implications for psychopathology
Salamone, John; Yohn, Samantha E.; López Cruz, Laura; San Miguel Segura, Noemí; Correa, Merce Oxford University Press (2016-04-26)Motivation has been defined as the process that allows organisms to regulate their internal and external environment, and control the probability, proximity and availability of stimuli. As such, motivation is a complex ... -
Adenosine A2A receptor antagonism and genetic deletion attenuate the effects of dopamine D2 antagonism on effort-based decision making in mice
Pardo Andrés, Marta; López Cruz, Laura; Valverde, Olga; LEDENT, Catherine; Baqi, Younis; Müller, Christa E.; Salamone, John; Correa, Merce Elsevier (2012)Brain dopamine (DA) and adenosine interact in the regulation of behavioral activation and effort-related processes. In the present studies, a T-maze task was developed in mice for the assessment of effort-related decision ... -
Adenosine A2A receptor deletion affects social behaviors and anxiety in mice: Involvement of anterior cingulate cortex and amygdala
López Cruz, Laura; Carbó Gas, María; Pardo, Marta; Bayarri Iturralde, Pilar; Valverde, Olga; LEDENT, Catherine; Salamone, John; Correa, Merce Elsevier (2017)Blockade of adenosine A2A receptors can potentiate motivation to work for natural reinforcers such as food. Conspecific interaction is a potent natural reinforcer in social animals that can be manifested as preference for ... -
c-Fos immunoreactivity in prefrontal, basal ganglia and limbic areas of the rat brain after central and peripheral administration of ethanol and its metabolite acetaldehyde
Segovia, Kristen N.; Vontell, Regina; López Cruz, Laura; Salamone, John; Correa, Merce Frontiers (2013)Considerable evidence indicates that the metabolite of ethanol (EtOH), acetaldehyde, is biologically active. Acetaldehyde can be formed from EtOH peripherally mainly by alcohol dehydrogenase (ADH), and also centrally by ... -
Caffeine and Selective Adenosine Receptor Antagonists as New Therapeutic Tools for the Motivational Symptoms of Depression
López Cruz, Laura; Salamone, John; Correa, Merce Frontiers Media (2018-06-01)Major depressive disorder is one of the most common and debilitating psychiatric disorders. Some of the motivational symptoms of depression, such anergia (lack of self-reported energy) and fatigue are relatively resistant ... -
Caffeine Modulates Food Intake Depending on the Context That Gives Access to Food: Comparison With Dopamine Depletion
Correa, Merce; San Miguel Segura, Noemí; López Cruz, Laura; Carratalá-Ros, Carla; Olivares-García, Régulo; Salamone, John (2018-09-06)Caffeine is a methylxanthine consumed in different context s to potentiate alertness and reduce fatigue. However, caffeine can induce anxiety at hig h doses. Caffeine is also a minor psychostimulant that seems to act ... -
Caffeine modulates voluntary alcohol intake in mice depending on theaccess conditions: Involvement of adenosine receptors and the role of individual differences
San Miguel Segura, Noemí; López Cruz, Laura; Müller, Christa E.; Salomone, John D.; Correa, Merce Elsevier (2019)Caffeine is the most consumed psychoactive stimulant and the main active ingredient of energy drinks.Epidemiology studies have shown a positive correlation between the consumption of energy drinks and that ofethanol. The ... -
Caffeine modulation of alcohol intake: impact on its psychomotor effects and withdrawal
Correa, Merce; SanMiguel, Noemí; López Cruz, Laura; Bayarri Iturralde, Pilar; Monferrer, Lidón; Salamone, John Nova Science Publishers (2014-04)Caffeine is a natural substance that is present in over 60 plant species. Alternative names include theine, guaranine and mateine. It is consumed by humans in the form of beverages such as coffee, tea, chocolate and soft ... -
Choosing voluntary exercise over sucrose consumption depends upon dopamine transmission: effects of haloperidol in wild type and adenosine A2AKO mice
Correa, Merce; Pardo Andrés, Marta; Bayarri Iturralde, Pilar; López Cruz, Laura; San Miguel Segura, Noemí; Valverde, Olga; LEDENT, Catherine; Salamone, John Springer (2016-02)Rationale: Mesolimbic dopamine (DA) regulates behavioral activation and effort-related decision-making in motivated behaviors. Mesolimbic DA D2 receptors are co-localized with adenosine A2A receptors, and they interact in ... -
Comparación de dosis altas de las metilxantinas cafeína y teofilina en efectos motores y ansiogénicos: estudio en modelos animales
López Cruz, Laura; Pardo, Marta; Dosda, Alicia; Salomone, John D.; Correa, Merce Universitat Jaume I (2011)La cafeína y la teofilina son metilxantinas que actúan como antagonistas no selectivos de la adenosina, activando dos tipos de receptores adenosinérgicos presentes en el sistema nervioso central: los A1 y los A2A. ... -
Deterioros motores producidos por los antipsicóticos típicos en muestras de ratones adultos jóvenes y viejos: Efecto terapeútico de los antagonistas de adenosina cafeína, teofilina y MSX-3
López Cruz, Laura; Fuentes-Claramonte, Paola; Pardo, Marta; Caballer, Gemma; Salamone, John; Correa, Merce Universitat Jaume I (2008)Uno de los efectos colaterales de la administración de neurolépticos para el tratamiento de los síntomas de la esquizofrenia es la afectación motora. Los antagonistas dopaminérgicos como el haloperidol, ampliamente ... -
Differences between the nonselective adenosine receptor antagonists caffeine and theophylline in motor and mood effects: Studies using medium to high doses in animal models
López Cruz, Laura; Pardo Andrés, Marta; Salamone, John; Correa, Merce Elsevier (2014-08)Rationale: Caffeine and theophylline are methylxanthines that are broadly consumed, sometimes at high doses, and act as minor psychostimulants. Both are nonselective adenosine antagonists for A1 and A2A receptors, which ... -
Dopamine depletion shifts behavior from activity based reinforcers tomore sedentary ones and adenosine receptor antagonism reversesthat shift: Relation to ventral striatum DARPP32 phosphorylationpatterns
López Cruz, Laura; SanMiguel, Noemí; Carratalá-Ros, Carla; Monferrer Sales, Lidón; Salamone, John; Correa, Merce Elsevier (2018)The mesolimbic dopamine (DA) system plays a critical role in behavioral activation and effort-baseddecision-making. DA depletion produces anergia (shifts to low effort options) in animals tested oneffort-based decision-making ... -
Dopaminergic modulation of effort-related choice behavior as assessed by a progressive ratio chow feeding choice task: pharmacological studies and the role of individual differences
Randall, Patrick A.; Pardo Andrés, Marta; Nunes, Eric J.; López Cruz, Laura; Vemuri, Venkata Kiran; Makriyannis, Alexandros; Baqi, Younis; Müller, Christa E.; Correa, Merce; Salamone, John Public Library of Science (2012)Mesolimbic dopamine (DA) is involved in behavioral activation and effort-related processes. Rats with impaired DA transmission reallocate their instrumental behavior away from food-reinforced tasks with high response ... -
Dosis medias y altas de cafeína no revierten la incoordinación motora producida por alcohol en ratones
San Miguel Segura, Noemí; López Cruz, Laura; Pardo Andrés, Marta; Correa, Merce Universitat Jaume I (2015)En los últimos años, el consumo de las bebidas energéticas ha incrementado notablemente, así como su concentración de cafeína. Con frecuencia, estas bebidas se consumen junto a grandes cantidades de alcohol con el objetivo ... -
Efecto ansiogénico y supresión motora inducidos por dosis altas de cafeína: Estudio en modelos animales
López Cruz, Laura; Pardo, Marta; Dosda, Alicia; Correa, Merce Universitat Jaume I (2009) -
Effect of subtype-selective adenosine receptor antagonists on basal or haloperidol-regulated striatal function: Studies of exploratory locomotion and c-Fos immunoreactivity in outbred and A2AR KO mice
Pardo Andrés, Marta; López Cruz, Laura; Valverde, Olga; LEDENT, Catherine; Baqi, Younis; Müller, Christa E.; Salamone, John; Correa, Merce Elsevier (2013-06-15)Behavioral activation is regulated by dopamine (DA) in striatal areas. At low doses, while typical antipsychotic drugs produce psychomotor slowing, psychostimulants promote exploration. Minor stimulants such as caffeine, ... -
Effects of lisdexamfetamine and s-citalopram, alone and in combination, on effort-related choice behavior in the rat
Yohn, Samantha E.; López Cruz, Laura; Hutson, Peter H.; Correa, Merce; Salamone, John Springer Verlag (2016)Rationale Effort-related motivational symptoms, such as anergia, psychomotor retardation, and fatigue, are an important aspect of depression and other disorders. Motivational symptoms are resistant to some treatments, ... -
El ejercicio forzado previene la anergia inducida por la depleción de dopamina. Estudios comparando la selección entre actividad física o la ingesta de alimentos dulces
Bayarri Iturralde, Pilar; Ros, Xavier; López Cruz, Laura; San Miguel Segura, Noemí; Monferrer Sales, Lidón; Correa, Merce Universitat Jaume I (2015)Disfunciones relacionadas con el esfuerzo como la anergia y la fatiga son síntomas centrales de la depresión y otros trastornos. El sistema dopaminérgico (DA) mesolímbico desempeña un papel crítico en la activación de ...