Listar por autoría "60005c2c-b7ca-46fb-8d2f-294f4ab48f3c"

Mostrando ítems 1-3 de 3

    • openAccess   Glycoside Hydrolase Catalysis: Do Substrates and Mechanism-Based Covalent Inhibitors React via Matching Transition States? 

      Akintola, Oluwafemi; Farren-Dai, Marco; Ren, Weiwu; Bhosale, Sandeep; Britton, Robert; Świderek, Katarzyna; Moliner, Vicent; Bennet, Andrew J. American Chemical Society (2023-12-02)
      In this study, we look at how a catalytically efficient α-galactosidase stabilizes transition state (TS) charge delocalization for substrate hydrolysis. We then assess whether covalent inhibition of the enzyme by three ...

    • openAccess   Glycoside hydrolase stabilization of transition state charge: new directions for inhibitor design 

      Ren, Weiwu; Farren-Dai, Marco; Sannikova, Natalia; Świderek, Katarzyna; Wang, Yang; Akintola, Oluwafemi; Britton, Robert; Moliner, Vicent; Bennet, Andrew J. Royal Society of Chemistry (2020)
      Carbasugars are structural mimics of naturally occurring carbohydrates that can interact with and inhibit enzymes involved in carbohydrate processing. In particular, carbasugars have attracted attention as inhibitors of ...

    • openAccess   Revealing the mechanism for covalent inhibition of glycoside hydrolases by carbasugars at an atomic level 

      Ren, Weiwu; Pengelly, Robert; Farren-Dai, Marco; Shamsi Kazem Abadi, Saeideh; Oehler, Verena; Akintola, Oluwafemi; Draper, Jason; Meanwell, Michael; Chakladar, Saswati; Świderek, Katarzyna; Moliner, Vicent; Britton, Robert; Gloster, Tracey M.; Bennet, Andrew J. Nature Research (2018)
      Mechanism-based glycoside hydrolase inhibitors are carbohydrate analogs that mimic the natural substrate’s structure. Their covalent bond formation with the glycoside hydrolase makes these compounds excellent tools for ...