Listar por autoría "4675efc3-c721-4278-8b22-3ab07d9b6364"
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Big dynorphin is a neuroprotector scaffold against amyloid β-peptide aggregation and cell toxicity
Gallego Villarejo, Lucia; Wallin, Cecilia; Król, Sylwia; Enrich Bengoa, Jennifer; Suades, Albert; Aguilella-Arzo, Marcel; Gómara Elena, María José; Haro, Isabel; Wärmlander, Sebastian; Muñoz, Francisco J.; Gräslund, Astrid; Perálvarez-Marín, Alex Elsevier (2022)Amyloid β-peptide (Aβ) misfolding into β-sheet structures triggers neurotoxicity inducing Alzheimer’s disease (AD). Molecules able to reduce or to impair Aβ aggregation are highly relevant as possible AD treatments since ... -
Structural biology workflow for the expression and characterization of functional human sodium glucose transporter type 1 in Pichia pastoris
Suades, Albert; Alcaraz, Antonio; Cruz, Esteban; Álvarez-Marimon, Elena; Whitelegge, Julian; Manyosa, Joan; Cladera, Josep; Perálvarez-Marín, Alex Nature Research (2019)Heterologous expression of human membrane proteins is a challenge in structural biology towards drug discovery. Here we report a complete expression and purification process of a functional human sodium/D-glucose co-transporter ...