• openAccess   A High Dietary Glycemic Index Increases Total Mortality in a Mediterranean Population at High Cardiovascular Risk 

      Castro-Quezada, Itandehui; Sánchez-Villegas, Almudena; Estruch, Ramon; Salas-Salvadó, Jordi; Corella, Dolores; Schoreder, Helmut; Álvarez-Pérez, Jacqueline; Ruiz-López, María Dolores; Artacho, Reyes; Ros, Emilio; Bulló, Mònica; Covas Planells, María Isabel; Ruiz-Gutiérrez, Valentina; Ruiz-Canela, Miguel; Buil-Cosiales, Pilar; Gómez-Gracia, Enrique; Lapetra, José; Pintó, Xavier; Arós, Fernando; Fiol Ramis, Miquel; Lamuela Raventós, Rosa María; Martínez González, Miguel Ángel; Serra-Majem, Lluis; PREDIMED Investigators Public Library of Science (2014)
      Objective: Different types of carbohydrates have diverse glycemic response, thus glycemic index (GI) and glycemic load (GL) are used to assess this variation. The impact of dietary GI and GL in all-cause mortality is ...
    • openAccess   Amino acid change in the carbohydrate response element binding protein is associated with lower triglycerides and myocardial infarction incidence depending on level of adherence to the Mediterranean diet in the PREDIMED trial 

      CAROLINA, ORTEGA-AZORÍN; Sorlí, José V; Estruch, Ramon; Asensio, Eva Maria; Coltell, Oscar; González, José I.; Martínez González, Miguel Ángel; Ros, Emilio; Salas-Salvadó, Jordi; Fitó, Montserrat; Arós, Fernando; Lapetra, José; Serra-Majem, Lluis; Ruiz-Gutiérrez, Valentina; Gómez Gracia, Enrique; Fiol Ramis, Miquel; Flores, Gemma; Pintó, Xavier; Sáiz, Carmen; Ordovás Muñoz, José M.; Corella, Dolores American Heart Association (2014-02)
      Background: A variant (rs3812316, C771G, Gln241His) in the MLXIPL (Max-like protein X interacting protein-like) gene encoding the carbohydrate response element binding protein has been associated with lower triglycerides. ...
    • openAccess   Associations of the FTO rs9939609 and the MC4R rs17782313 polymorphisms with type 2 diabetes are modulate by diet, being higher when adherence to the Mediterranean diet pattern is low 

      Coltell, Oscar; Martínez González, Miguel Ángel; Salas-Salvadó, Jordi; Arós, Fernando; Lapetra, José; Serra-Majem, Lluis; Gómez Gracia, Enrique; Fiol Ramis, Miquel; Sáez Tormo, Guillermo; Pintó, Xavier; Muñoz, Miguel Ángel; Ordovás Muñoz, José M.; Estruch, Ramon; Corella, Dolores; CAROLINA, ORTEGA-AZORÍN; Sorlí, José V; Asensio, Eva Maria; Covas Planells, María Isabel; Ros, Emilio BioMed Central (2012-11)
      Background: Although the Fat Mass and Obesity (FTO) and Melanocortin-4 Receptor (MC4R) genes have been consistently associated with obesity risk, the association between the obesity-risk alleles with type 2 diabetes is ...
    • openAccess   CLOCK gene variation is associated with incidence of type-2 diabetes and cardiovascular diseases in type-2 diabetic subjects: dietary modulation in the PREDIMED randomized trial 

      Corella, Dolores; Asensio, Eva Maria; Coltell, Oscar; Sorlí, José V; Estruch, Ramon; Martínez González, Miguel Ángel; Castañer, Olga; Arós, Fernando; Lapetra, José; Serra-Majem, Lluis; Gómez Gracia, Enrique; CAROLINA, ORTEGA-AZORÍN; Fiol Ramis, Miquel; Díez Espino, Javier; Díaz López, Andrés; Fitó, Montserrat; Ros, Emilio; Ordovás Muñoz, José M. BioMed Central (2016-01)
      Background Circadian rhythms regulate key biological processes influencing metabolic pathways. Disregulation is associated with type 2 diabetes (T2D) and cardiovascular diseases (CVD). Circadian rhythms are generated by ...
    • closedAccess   Cohort Profile: Design and methods of the PREDIMED-Plus randomized trial 

      Martínez González, Miguel Ángel; Buil-Cosiales, Pilar; Corella, Dolores; Bulló, Mònica; Fitó, Montserrat; Vioque, Jesus; Romaguera, Dora; Martínez, J. Alfredo; Wärnberg, Julia; López Miranda, José; Estruch, Ramon; Bueno Cavanillas, Aurora; Arós, Fernando; Tur, Josep; Tinahones Madueño, Francisco José; Serra-Majem, Lluis; Martín, Vicente; Lapetra, José; Vázquez, Clotilde; Pintó, Xavier; Vidal, Josep; Daimiel-Ruiz, Lidia Ángeles; Delgado Rodríguez, Miguel; Matía, Pilar; Ros, Emilio; Fernández Aranda, Fernando; Botella, Cristina; Puy Portillo-Baquedano, María; Lamuela Raventós, Rosa María; Marcos, Ascensión; Sáez, Guillermo; Gómez-Gracia, Enrique; Ruiz-Canela, Miguel; Toledo, Estefanía; Alvarez-Alvarez, Ismael; Díez Espino, Javier; Sorlí, José V; Basora, Josep; Castañer, Olga; Schröder, Helmut; Navarrete-Muñoz, Eva María; Zulet, M. Angeles; García-Rios, Antonio; Salas-Salvadó, Jordi Oxford University Press (2019-04)
      The PREDIMED (in Spanish: PREvención con DIeta MEDiterránea) primary prevention trial1–3 reported in 2013 that long-term adherence to an energy-unrestricted Mediterranean diet (MedDiet), supplemented with either extra-virgin ...
    • closedAccess   Intake of Total Polyphenols and Some Classes of Polyphenols Is Inversely Associated with Diabetes in Elderly People at High Cardiovascular Disease Risk 

      Tresserra-Rimbau, Anna; Guash-Ferré, Marta; Salas-Salvadó, Jordi; Toledo, Estefanía; Corella, Dolores; Castañer, Olga; Guo, Xiaohui; Gómez Gracia, Enrique; Lapetra, José; Arós, Fernando; Fiol Ramis, Miquel; Ros, Emilio; Serra-Majem, Lluis; Pintó, Xavier; Fitó, Montserrat; Babio, Nancy; Martínez González, Miguel Ángel; Sorlí, José V; López-Sabater, Maria Carmen; Estruch, Ramon; Lamuela Raventós, Rosa María; Coltell, Oscar; PREDIMED Investigators American Society for Nutrition (2016-03)
      Background: Higher consumption of some polyphenols has been associated with a reduced risk of diabetes. However, no studies have evaluated the relation between all polyphenol subclasses and the incidence of diabetes. Objective: ...
    • closedAccess   Inverse association between habitual polyphenol intake and incidence of cardiovascular events in the PREDIMED study 

      Tresserra-Rimbau, Anna; Rimm, Eric B.; Medina Remón, A.; Martínez González, Miguel Ángel; De la Torre, R.; Corella, Dolores; Salas-Salvadó, Jordi; Gómez Gracia, Enrique; Lapetra, José; Arós, Fernando; Fiol Ramis, Miquel; Ros, Emilio; Serra-Majem, Lluis; Pintó, Xavier; Sáez Tormo, Guillermo; Basora, Josep; Sorlí, José V; Martínez, J. Alfredo; Vinyoles, E.; Ruiz-Gutiérrez, Valentina; Estruch, Ramon; Lamuela Raventós, Rosa María; Coltell, Oscar Elsevier (2016-06)
      Background and aims Epidemiologic and biological evidence supports an inverse association between polyphenol consumption and the risk of cardiovascular disease (CVD). However, no previous studies have prospectively ...
    • openAccess   Mediterranean Diet Reduces the Adverse Effect of the TCF7L2-rs7903146 Polymorphism on Cardiovascular Risk Factors and Stroke Incidence 

      Corella, Dolores; Carrasco, Paula; Sorlí, José V; Estruch, Ramon; Rico Sanz, Jesús; Martínez González, Miguel Ángel; Salas-Salvadó, Jordi; Covas Planells, María Isabel; Coltell, Oscar; Arós, Fernando; Lapetra, José; Serra-Majem, Lluis; Ruiz-Gutiérrez, Valentina; Warnberg, Julia; Fiol Ramis, Miquel; Pintó, Xavier; CAROLINA, ORTEGA-AZORÍN; Muñoz, Miguel Ángel; Martínez, J. Alfredo; Gómez Gracia, Enrique; González, José I.; Ros, Emilio; Ordovás Muñoz, José M. American Diabetes Association (2013)
      OBJECTIVE Transcription factor 7-like 2 (TCF7L2) polymorphisms are strongly associated with type 2 diabetes, but controversially with plasma lipids and cardiovascular disease. Interactions of the Mediterranean diet (MedDiet) ...
    • closedAccess   MicroRNA-410 regulated lipoprotein lipase variant rs13702 is associated with stroke incidence and modulated by diet in the randomized controlled PREDIMED trial 

      Corella, Dolores; Sorlí, José V; Estruch, Ramon; Coltell, Oscar; CAROLINA, ORTEGA-AZORÍN; Portolés, Olga; Martínez González, Miguel Ángel; Bulló, Mònica; Fitó, Montserrat; Arós, Fernando; Lapetra, José; Asensio, Eva Maria; Sáez Tormo, Guillermo; Serra-Majem, Lluis; Muñoz Bravo, Carlos; Ruiz-Gutiérrez, Valentina; Fiol Ramis, Miquel; Vinyoles, Ernest; Pintó, Xavier; Richardson, Kris; Ros, Emilio; Ordovás Muñoz, José M. American Society for Nutrition (2014-08)
      Background: MicroRNAs have emerged as important epigenetic regulators in cardiovascular diseases (CVDs). Using an observational meta-analysis design, we previously characterized a gain-of-function microRNA-410 target site ...
    • openAccess   Novel association of the obesity risk-allele near Fas Apoptotic Inhibitory Molecule 2 (FAIM2) gene with heart rate and study of its effects on myocardial infarction in diabetic participants of the PREDIMED trial 

      Corella, Dolores; Sorlí, José V; González, José I.; CAROLINA, ORTEGA-AZORÍN; Fitó, Montserrat; Bulló, Mònica; Martínez González, Miguel Ángel; Ros, Emilio; Arós, Fernando; Lapetra, José; Gómez Gracia, Enrique; Serra-Majem, Lluis; Ruiz-Gutiérrez, Valentina; Fiol Ramis, Miquel; Coltell, Oscar; Vinyoles, Ernest; Pintó, Xavier; Martí, Amelia; Sáiz, Carmen; Ordovás Muñoz, José M.; Estruch, Ramon BioMed Central (2014-01)
      Background: The Fas apoptotic pathway has been implicated in type 2 diabetes and cardiovascular disease. Although a polymorphism (rs7138803; G > A) near the Fas apoptotic inhibitory molecule 2 (FAIM2) locus has been related ...
    • closedAccess   PREDIMED Investigators 

      Díez Espino, Javier; Basterra-Gortari, Francisco Javier; Salas-Salvadó, Jordi; Buil-Cosiales, Pilar; Corella, Dolores; Schröder, Helmut; Estruch, Ramon; Ros, Emilio; Gómez-Gracia, Enrique; Arós, Fernando; Fiol Ramis, Miquel; Lapetra, José; Serra-Majem, Lluis; Pintó, Xavier; Babio, Nancy; Quiles Guiñau, Laura; Fitó, Montserrat; Marti, Amelia; Toledo, Estefanía; PREDIMED Investigators Elsevier (2017)
      Background Eggs are a major source of dietary cholesterol and their consumption has been sometimes discouraged. A relationship between egg consumption and the incidence of cardiovascular disease (CVD) has been suggested ...
    • openAccess   Statistical and biological gene-lifestyle interactions of MC4R and FTO with Diet and physical activity on obesity: new effects on alcohol consumption 

      Corella, Dolores; CAROLINA, ORTEGA-AZORÍN; Sorlí, José V; Covas Planells, María Isabel; Carrasco, Paula; Salas-Salvadó, Jordi; Martínez González, Miguel Ángel; Arós, Fernando; Lapetra, José; Serra-Majem, Lluis; Lamuela Raventós, Rosa María; Gómez García, Enrique; Fiol Ramis, Miquel; Pintó, Xavier; Ros, Emilio; Martí, Amelia; Coltell, Oscar; Ordovás Muñoz, José M.; Estruch, Ramon Public Library of Science (2012)
      Background: Fat mass and obesity (FTO) and melanocortin-4 receptor (MC4R) and are relevant genes associated with obesity. This could be through food intake, but results are contradictory. Modulation by diet or other ...
    • openAccess   Total and Subtypes of Dietary Fat Intake and Its Association with Components of the Metabolic Syndrome in a Mediterranean Population at High Cardiovascular Risk 

      Julibert, Alicia; Bibiloni, Maria del Mar; Bouzas Velasco, Cristina; Martínez González, Miguel Ángel; Salas-Salvadó, Jordi; Corella, Dolores; Zomeño, Maria Dolors; Romaguera, Dora; Vioque, Jesus; Alonso-Gómez, Ángel M.; Wärnberg, Julia; Martínez, J. Alfredo; Serra-Majem, Lluis; Estruch, Ramon; Tinahones, Francisco J.; Lapetra, José; Pintó, Xavier; López Miranda, José; García-Molina, Laura; Gaforio, Jose J; Matía-Martín, Pilar; Daimiel-Ruiz, Lidia Ángeles; Martín Sánchez, Vicente; Vidal, Josep; Vázquez, Clotilde; Ros, Emili; Toledo, Estefanía; Becerra-Tomás, Nerea; Portolés, Olga; Pérez-Vega, Karla A.; Fiol Ramis, Miquel; Torres-Collado, Laura; Tojal-Sierra, Lucas; Carabaño-Moral, Rosa; Abete, Itziar; Sanchez Villegas, Almudena; Casas, Rosa; Bernal López, María Rosa; Santos Lozano, José Manuel; Galera, Ana; Ugarriza, Lucía; Ruiz-Canela, Miguel; Babio, Nancy; Coltell, Oscar; Schröder, Helmut; Konieczna, Jadwiga; Orozco Beltrán, Domingo; Sorto-Sánchez, Carolina; Eguaras, Sonia; Barrubés, Laura; Fitó, Montserrat; Tur, Josep A.; PREDIMED-PLUS Investigators MDPI (2019)
      Background: The effect of dietary fat intake on the metabolic syndrome (MetS) and in turn on cardiovascular disease (CVD) remains unclear in individuals at high CVD risk. Objective: To assess the association between fat ...