2024-03-29T10:28:47Zhttps://repositori.uji.es/oai/requestoai:repositori.uji.es:10234/730662021-06-10T17:57:54Zcom_10234_36080com_10234_9col_10234_36082
Repositori UJI
author
Barcia, Carlos
author
Ros Gómez, Carmen María
author
Ros Bernal, Francisco
author
Gómez, Aurora
author
Annese, Valentina
author
Carrillo-de Sauvage, María Ángeles
author
Yuste Jiménez, José Enrique
author
Campuzano Brando, Carmen María
author
De Pablos, Vicente
author
Fernández Villalba, Emiliano
author
Herrero Ezquerro, María Trinidad
2013-09-20T14:27:32Z
2013-09-20T14:27:32Z
2013
Journal of Neuroimmunology Volume 261, Issue 1 , Pages 60-66, 15 August 2013
0165-57281872-8421
http://hdl.handle.net/10234/73066
http://dx.doi.org/10.1016/j.jneuroim.2013.05.001
Patients with Parkinson's disease show persistent microglial activation in the areas of the brain where the degeneration of dopaminergic neurons takes place. The reason for maintaining this activated state is still unknown, but it is thought that this persistent microglial activation may contribute to the degeneration of dopaminergic neurons. In this study, we report the microanatomical details of microglia and the relationship between microglia and neurons in the substantia nigra pars compacta of Parkinsonian monkeys years after insult with MPTP. We observed that microglial cells appear polarized toward dopaminergic neurons in MPTP-treated macaques compared to untreated animals and present clear phagocytic characteristics, such as engulfing gliaptic contacts, an increase in Golgi apparatus protein machinery and ball-and-chain phagocytic buds. These results demonstrate that activated microglia maintain phagocytic characteristics years after neurotoxin insult, and phagocytosis may be a key contributor to the neurodegenerative process.
eng
Copyright © 2013 Elsevier Inc. All rights reserved.This is the author’s version of a work that was accepted for publication in Journal of Neuroimmunology. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Journal of Neuroimmunology
Volume 261, Issue 1 , Pages 60-66, 15 August 2013 DOI10.1016/j.jneuroim.2014.05.001
Parkinson's disease
MPTP
Dopaminergic degeneration
Cell polarity
Inflammation
Microglial motility
Persistent phagocytic characteristics of microglia in the substantia nigra of long-term Parkinsonian macaques
info:eu-repo/semantics/article
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