2024-03-29T14:17:46Zhttps://repositori.uji.es/oai/requestoai:repositori.uji.es:10234/517392022-12-13T15:07:32Zcom_10234_7013com_10234_9col_10234_8638
Repositori UJI
author
Fidelak, Jeremy
author
Ferrer Castillo, Silvia
author
Oberlin, Michael
author
Moras, Dino
author
Dejaegere, Annick
author
Stote, Roland H.
2012-11-12T18:47:38Z
2012-11-12T18:47:38Z
2010
European Biophysics Journal (2010), 39, 11 , p. 1503-1512
0175-7571
http://hdl.handle.net/10234/51739
http://dx.doi.org/10.1007/s00249-010-0608-9
Peroxisome proliferator-activated receptor-γ nuclear receptor (PPAR-γ) belongs to the superfamily of nuclear receptor proteins that function as ligand-dependent transcription factors and plays a specific physiological role as a regulator of lipid metabolism. A number of experimental studies have suggested that allostery plays an important role in the functioning of PPAR-γ. Here we use normal-mode analysis of PPAR-γ to characterize a network of dynamically coupled amino acids that link physiologically relevant binding surfaces such as the ligand-dependent activation domain AF-2 with the ligand binding site and the heterodimer interface. Multiple calculations were done in both the presence and absence of the agonist rosiglitazone, and the differences in dynamics were characterized. The global dynamics of the ligand binding domain were affected by the ligand, and in particular, changes to the network of dynamically correlated amino acids were observed with only small changes in conformation. These results suggest that changes in dynamic couplings can be functionally significant with respect to the transmission of allosteric signals.
eng
(c) European Biophysical Societies’ Association 2010
Molecular dynamics
Nuclear receptor
Allostery
Normal mode
Protein
Dynamic correlation networks in human peroxisome proliferator-activated receptor-γ nuclear receptor protein
info:eu-repo/semantics/article
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