2024-03-29T11:50:40Zhttps://repositori.uji.es/oai/requestoai:repositori.uji.es:10234/1604072021-09-15T07:59:47Zcom_10234_8033com_10234_9col_10234_8636
Repositori UJI
author
Pascual, María
author
Baliño, Pablo
author
González Aragón, Carlos Manuel
author
Guerri, Consuelo
2016-06-07T11:56:13Z
2016-06-07T11:56:13Z
2015
PASCUAL, María, et al. Cytokines and chemokines as biomarkers of ethanol-induced neuroinflammation and anxiety-related behavior: role of TLR4 and TLR2. Neuropharmacology, 2015, vol. 89, p. 352-359.
0028-39081873-7064
http://hdl.handle.net/10234/160407
http://dx.doi.org/10.1016/j.neuropharm.2014.10.014
Recent evidence supports the influence of neuroimmune system activation on behavior. We have demonstrated that ethanol activates the innate immune system by stimulating toll-like receptor 4 (TLR4) signaling in glial cells, which triggers the release of inflammatory mediators and causes neuroinflammation. The present study aimed to evaluate whether the ethanol-induced up-regulation of cytokines and chemokines is associated with anxiety-related behavior, 24 h after ethanol removal, and if TLR4 or TLR2 is involved in these effects. We used WT, TLR4-KO and TLR2-KO mice treated with alcohol for 5 months to show that chronic ethanol consumption increases the levels of cytokines (IL-1β, IL-17, TNF-α) and chemokines (MCP-1, MIP-1α, CX3CL1) in the striatum and serum (MCP-1, MIP-1α, CX3CL1) of WT mice. Alcohol deprivation for 24 h induces IFN-γ levels in the striatum and maintains high levels of some cytokines (IL-1β, IL-17) and chemokines (MIP-1α, CX3CL1) in this brain region. The latter events were associated with an increase in anxiogenic-related behavior, as evaluated by the dark and light box and the elevated plus maze tests. Notably, mice lacking TLR4 or TLR2 receptors are largely protected against ethanol-induced cytokine and chemokine release, and behavioral associated effects during alcohol abstinence. These data support the role of TLR4 and TLR2 responses in neuroinflammation and in anxiogenic-related behavior effects during ethanol deprivation, and also provide evidence that chemokines and cytokines can be biomarkers of ethanol-induced neuroimmune response.
eng
Copyright © Elsevier B.V.
TLR4
ethanol
anxiety
withdrawal
neuroinflammation
cytokines
Cytokines and chemokines as biomarkers of ethanol-induced neuroinflammation and anxiety-related behavior: Role of TLR4 and TLR2
info:eu-repo/semantics/article
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