2024-03-29T07:47:20Zhttps://repositori.uji.es/oai/requestoai:repositori.uji.es:10234/1586052022-10-19T07:09:08Zcom_10234_7053com_10234_9col_10234_8639
Repositori UJI
author
Gorczyca, Marcelina
author
Korchowiec, Beata
author
Korchowiec, Jacek
author
Trojan, Sonia
author
RUBIO-MAGNIETO, JENIFER
author
Luis, Santiago V.
author
Rogalska, Ewa
2016-04-14T11:08:23Z
2016-04-14T11:08:23Z
2015-05
GORCZYCA, Marcelina, et al. A Study of the Interaction between a Family of Gemini Amphiphilic Pseudopeptides and Model Monomolecular Film Membranes Formed with a Cardiolipin. The Journal of Physical Chemistry B, 2015, vol. 119, no 22, p. 6668-6679.
http://hdl.handle.net/10234/158605
http://dx.doi.org/10.1021/acs.jpcb.5b02575
The interaction between five gemini amphiphilic pseudopeptides (GAPs) differing by the length of the central spacer and a model membrane lipid, 1,3-bis[1,2-dimyristoyl-sn-glycero-3-phospho]-sn-glycerol (cardiolipin) were studied with the aim to evaluate their possible antimicrobial properties. To this end, monomolecular films were formed at the air/water interface with pure cardiolipin or cardiolipin/GAPs mixtures; film properties were determined using surface pressure and surface potential measurements, as well as polarization-modulation infrared reflection–absorption spectroscopy. Moreover, to better understand the GAPs-phospholipid interaction at the molecular level, molecular dynamics simulations were performed. The results obtained indicate that the length of the central spacer has an effect on the interaction of GAPs with cardiolipin and on the properties of the lipid film. The GAPs with the longer linkers can be expected to be useful for biological membrane modification and for possible antimicrobial applications.
eng
© 2015 American Chemical Society
Gemini amphiphilic pseudopeptides
Cell Membrane
Cardiolipin
Absorption spectroscopy
Phospholipids
A Study of the Interaction between a Family of Gemini Amphiphilic Pseudopeptides and Model Monomolecular Film Membranes Formed with a Cardiolipin
info:eu-repo/semantics/article
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