2024-03-29T14:17:05Zhttps://repositori.uji.es/oai/requestoai:repositori.uji.es:10234/1267792024-03-26T08:28:50Zcom_10234_2507com_10234_9col_10234_6973
Repositori UJI
author
Aguilella, Vicente
author
Verdiá Báguena, Carmen
author
Alcaraz, Antonio
2015-07-08T17:34:00Z
2015-07-08T17:34:00Z
2014
Phys. Chem. Chem. Phys., 2014, 16, 3881
1463-90761463-9084
http://hdl.handle.net/10234/126779
http://dx.doi.org/10.1039/c3cp54690j
Ion channels are specialized proteins that enable the movement of charges through otherwise impermeable lipidic membranes. Their action is essential in living organisms facilitating electric signaling, muscle contraction or osmotic stress response among other effects. The protein and the lipid charges configure a polarized interface that yields local ionic concentrations and electric potentials that are very different from those of the bulk electrolyte. The combined effect of gradients of ionic concentration and electric potential causes the transport of ions through channels. Here we analyze charge regulation effects in different protein–lipid conformations, stressing how important is the role of electrostatic interactions in the ion channel function that traditionally has been rationalized paying attention mainly to changes in pore size. Tuning lipid charge combined with conductance and selectivity measurements is shown to be a complementary method to evidence lipid involvement in the structure of a biological ion channel.
eng
This journal is © the Owner Societies 2014
Lipid charge regulation of non-specific biological ion channels
info:eu-repo/semantics/article
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